Protein
Zinc metalloproteinase/disintegrin
Organism
Deinagkistrodon acutus
Function
Disintegrin acugrin: inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3) (By similarity).
Similarity
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
Sequence
MIQVLLVTICLAAFPYQGSSIILESGKVNDYEVVYPQRLAPLPEGAVQQKYEDTMQYEFKVNGEPVVLHLEKNKGLFSKDYSEIHYSPDGRRITTHPLVEDHCYYRGHIRNDADSTASISACHGLKGHFKLRGETYLIEPMKISNSEAHAVYKYENVEKEDEAHKMCGVTQNWESYEPIKKASQLIVSTEQQRYMEIVIVVDHSMVKKYNGDSDKIKAWVYEMINTITESYRYLYIDIILSGLEIWSEKDLINVETSAENTLKSFGEWRAKDLIHRISHDNAQLLTATDLDGPTIGLAYVASMCDPKRSVGIVQDHSSVNRLVAITLAHEMAHNLGVRHDEGSCSCGSGYTCIMSPVINPDAMKYFSDCSYIQCWDYIMKENPPCILNKPLRTDTVSTPVSGNELLEAGKDYDRDSSANPCYDAATCKLNQGAQCTAGPCCDQGRFKEEGTICRRARGDDLDDYCNGISADCPRNPYHA