washc5

WASH complex subunit 5

1164 amino acids

Belongs to the strumpellin family.

134.897 kDa

MVKEFLGEGSQAGQNLLRLVSRGNAIIAELLRLSAHIPSVFKLEDRNEARKYQDILLDFKYLSNPDFYESKIEENADLVDLETEFRDNHIDILIRFYHLFESIYKYIMDLEHYIVDVEKGFYIHLTIEAILINGDGKQLLSEAVYLYGVMLILMDNLIEGPVRERMLISYLRNKGPVDLPLIDEVCKLCKSTGYIPGSPKKPPNYPEEYFRRVELPENVISMIVGRLRSDDLYNGTESFPQPEHRSVALSTQACMIYVILYFIPDILNNKNSIMREIVDKFFPDNWVISFFLGFTIDLSVAWEPYKAAKTAMGNTIIQSNIQYQTQRFWKEVSELNKLVDDLLVDGLLVEEYIVDNVHKIITTLRRCNVTIRWVMLHSNASQKKFKDLVLMGGSQEDVLYLLLNTAQLEFVFKNIFQQLLATKEEKWEENKKLASDSMVELSEYFSGEKALTRVKKNENLQKWFGEISQKISQLDSTDSTSTGRKIQQLSLALEEVEQFQQIDSSIQVKQFLIETRQFLTKMIKIVNIKEEVLVNLSVCADMSYAWEIVNNYVDQMQKGIKSDPKCVLKLRATFLKLVSILDLPLVRIAQCSSPDLISVSEYYSGELVGYVRKVLEIVPKQMFLILKQIINMQTNNIQEMPTKVEKERLRDFAQLDQRYDLARATHSVSVFTEGILAMETTLVGIIEVDPKQLLEDGIRKELVLQIALAMDKTLIFSGKPYQAPSNKQQQQEIELLQRLKELSNILDGFRRSFQYIQDYVNIQGLKIWQEEFSRIVNFYVEQECNSFLKKKVYDWQSQYQSVAIPIPKFPSQSDQNSQQSVNMIGRLARELLNQTNCKTTLYLNQIGWFDPSSGKELVGINTWSILHQSVGIFGLTGLDKLFSFMMVKDLQVFVSQTRSLVEKSLKGFLNEFEDYLRPTTNIPDTMIRYQQALDKTKLLYPIFIDVLTKIGQIQLIRRQISNQLNFHCKIDSNMLFSSLDIMNKSLLNDIESHFQRPDSNPYPSDDNTLLFDLAQYLDTAGINDPFTKIYITTSPLEQFPCLLFLFVLSQVSKFQFNSKLNVMSSKKQKNSYDWTPFIIGCITILQQFHSLHTQKFLAFVGQYIKSHINIALANPKENNKDDADYPEDVIGLLRFLEDFCKYSHTSRKIVEGYVPPYIFDYYNN

washc5

WASH complex subunit 5

1159 amino acids

Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting.

Belongs to the strumpellin family.

133.599 kDa

MVDFLAENNLCGQAILRIVSRGNAIIAELLRLSDFIPAVFRLRDKTDQQKYGDIICDFSYFKGPEYYEGKLEAKPELQDLDEEFRENNIEILTRFYLAFESVHKYVVDLIRCLDDLNEGVYIQQTLETVLLNEDGKQLLCEALYLYGVMLLVIDQKMEGEVRERMLVSYYRYSAARSSADSNLDDICKLLRSTGYSSHPGAKRPTNYPESYFQRVPISSTFISMVIGRLRSDDIYNQVSAYPLPEHRSTALATQAAMLYVCLYFTPSILHTQQAKMREIVDKYFPDNWVISIYMGITVNLVEAWEPYKAAKIALNYTLDTANIREQAGRYAASVETLRPQVQQLLKEGFLREEIILDNIPKLLNCLRDCNVAIRWLMLHTAESAYDPNNKRLRQIKDQVINDSKYNPKILFQLLLDTAQFEFILKEMFKQMLAEKQLKWESYKKEGSERMMELAEVFSGVKPLTRVEKNENLQAWFREISKQIESLNYEDSTAAGRKTVQLIQALVEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITMQIVGDLSYAWQIIDSFTAIMQESIRANPSMVTKLRATLLKLASALDLPLLRINQVNSPDLLSVSQFYSGELVAYVRKVLQIIPESMFTSLAKIIKLQIHDIMEVPTRLDKDKLKDYSQLSARYEVAKLTHAISVFTEGILMMKTTLVGIIQVDPKQLLEDGIRKELVKRVAYALHKGLIFNPKAKPSELMPKLKEMAATMDGFYRSFEYIQDYVSIYGLKIWQEEVSRIINYNVEQECNSFLRTKIQDWQSVHQSTHIPIPKYPSVDESATFIGRLCREILRITDPKVTCYIDQLNTWYDLRTHQEVTNNRLFSEIQDTLGTFGLNGLDRLLCFMIVKELQNFLTVLQKSILKDKAVVDVFKALLTAVNPVKGIVANASKVYTNAAAKTQKIWSPYLESIMKVGQMQILRQQIANELNYSCKFDSKHLAAALDNLNKSLLSDIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKSQGMACRKPADALDWAPLVLGLLTLLKQFHSRYTEQFLALIGQFIRSIMEQCTSQKIPDMPSDVVGALMFLEDYVRYTKLPRKVAEAHVPSFIFDEFRTVL

WASHC5

WASH complex subunit 5

1159 amino acids

Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666).

Belongs to the strumpellin family.

134.286 kDa

MLDFLAENNLCGQAILRIVSCGNAIIAELLRLSEFIPAVFRLKDRADQQKYGDIIFDFSYFKGPELWESKLDAKPELQDLDEEFRENNIEIVTRFYLAFQSVHKYIVDLNRYLDDLNEGVYIQQTLETVLLNEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVSYYRYSAARSSADSNMDDICKLLRSTGYSSQPGAKRPSNYPESYFQRVPINESFISMVIGRLRSDDIYNQVSAYPLPEHRSTALANQAAMLYVILYFEPSILHTHQAKMREIVDKYFPDNWVISIYMGITVNLVDAWEPYKAAKTALNNTLDLSNVREQASRYATVSERVHAQVQQFLKEGYLREEMVLDNIPKLLNCLRDCNVAIRWLMLHTADSACDPNNKRLRQIKDQILTDSRYNPRILFQLLLDTAQFEFILKEMFKQMLSEKQTKWEHYKKEGSERMTELADVFSGVKPLTRVEKNENLQAWFREISKQILSLNYDDSTAAGRKTVQLIQALEEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITMQIVGDLSFAWQLIDSFTSIMQESIRVNPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVSYVRKVLQIIPESMFTSLLKIIKLQTHDIIEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVKRVAFALHRGLIFNPRAKPSELMPKLKELGATMDGFHRSFEYIQDYVNIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFTPVDESVTFIGRLCREILRITDPKMTCHIDQLNTWYDMKTHQEVTSSRLFSEIQTTLGTFGLNGLDRLLCFMIVKELQNFLSMFQKIILRDRTVQDTLKTLMNAVSPLKSIVANSNKIYFSAIAKTQKIWTAYLEAIMKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFICSTVEQCTSQKIPEIPADVVGALLFLEDYVRYTKLPRRVAEAHVPNFIFDEFRTVL

Washc5

WASH complex subunit 5

1159 amino acids

Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (By similarity). Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation (PubMed:24998208).

Belongs to the strumpellin family.

134.11 kDa

MLDFLAENNLCGQAILRIVSCGNAIIAEVLRLSEFIPAVFLLKDRADQQRYGDIIFDFSYFKGPEFWESKLEAKPELQDLDEEFRENNIEIVTRFYLAFQSVHKYIVDLNRYLDDLNEGVYIQQTLETVLLSEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVSYYRYSAARSSADSNMDDICKLLRSTGYSSQPGAKRPPNYPESYFQRVPINETFISMVIGRLRSDDIYNQVSAYPLPEHRSTALANQAAMLYVILYFEPSILHTHQAKMREIVDKYFPDNWVISIYMGITVNLADAWEPYKAAKTALNNTLDLANVKEQASRYASVSDRVRAQVQQFLKEGYLREEVLLDNIPRLLNCLRDCNVAIRWLMLHTADSACDPNNKRLRQIKDQILADSRYNPKILFQLLLDTAQFEFILKEMFKQMLSEKQSKWEHYKKEGSERMTELADVFSGVKPLTRVEKNENLQAWFREISKQILSLNYDDSTAAGRKTVQLIQALEEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITVQIIGDLSFAWQLIDSFTSIMQESIRVNPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVSYVRKVLQIIPESMFTSLLKIIKLQTHDIMEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVKRVAFALHRGLIFNPRAKPSELMPKLKELGATMDGFHRSFEYIQDYVSIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFAPVDESITFIGRLCREILRITDPKMTCYIDQLNTWYDVKTHQEVTSSRLFSEIQTTLGTFGLNGLDRLLCFMIVKELQNFLSMFQKIILKERTVQETLKMLMSAVNPLKSIVANSSKVYLSAITKTQKIWSAYLEAIMKVGQMQILRQQIANELNSSCRFDSRHLAAALDNLNKALLADIEAHYRDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPADPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFIRSTMEQCTSQKMPEMPADAVGALLFLEDYVRYTKLPRRVAEAHVPNFIFDEFRTVL

WASHC5

WASH complex subunit 5

1159 amino acids

Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (By similarity).

Belongs to the strumpellin family.

134.296 kDa

MLDFLAENNLCGQAILRIVSCGNAIIAELLRLSEFIPAVFRLKDRADQQKYGDIIFDFSYFKGPELWESKLDAKPELQDLDEEFRENNIEIVTRFYLAFQSVHKYIVDLNRYLDDLNEGVYIQQTLETVLLNEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVSYYRYSAARSSADSNMDDICKLLRSTGYSSQPGARRPPNYPESYFQRVPINESFISMVIGRLRSDDIYNQVSAYPLPEHRSTALANQAAMLYVILYFEPSILHTHQAKMREIVDKYFPDNWVISIYMGITVNLVDAWEPYKAAKTALNNTLDLSNVREQASRYATVSERVHAQVQQFLKEGYLREEMVLDNIPKLLNCLRDCNVAIRWLMLHTADSACDPNNKRLRQIKDQILTDSRYNPRILFQLLLDTAQFEFILKEMFKQMLSEKQTKWEHYKKEGSERMTELADVFSGVKPLTRVEKNENLQAWFREISKQILSLNYDDSTAAGRKTVQLIQALEEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITMQIVGDLSFAWQLIDSFTSIMQESIRVNPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVSYVRKVLQIIPESMFTSLLKIIKLQTHDIIEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVKRVAFALHRGLIFNPRAKPSELMPKLKELGATMDGFHRSFEYIQDYVNIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFTPVDESVTFIGRLCREILRITDPKMTCHIDQLNTWYDMKTHQEVTSSRLFSEIQTTLGTFGLNGLDRLLCFMIVKELQNFLSMFQKIILRDRTVQDTLKTLMNAVSPLKSIVANSNKIYFSAIAKTQKIWTAYLEAIMKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSLPYPKEDNTLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVCRKPTDPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFICSTVEQCTSQKIPEIPADVVGALLFLEDYARYTKLPRRVAEAHVPNFIFDEFRTVL

washc5

WASH complex subunit 5

1159 amino acids

Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting.

Belongs to the strumpellin family.

134 kDa

MVDFLAENNLCGQAILRIVSRGNAIIAELLRLSEFVPSVFRLKDKADQQKYGDIIFDFSYFKGPEVCEGRLEAKPELQDLDEEFRENNIEILTRFYLAFESVHKYIVDLNRYLEDLNEGIYIQQTLETVLLNEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVAYYRYSAARSSVDSNMDDICKLLRSTGYSSQPGAKRPPNYPESYFSRVPISETFISMVIGRLRSDDIYNQVSAYPLPEHRSTALATQAAILYVILYFHPPTLHTHQAKMREIVDKYFPDNWVISIYMGITVNLMEVWEPYKAAKTALNYTLDLPNIKEQASRYAKIIESLHPQVQQFLKEGFLREEFVLDNIPKLLNCLRDCNVAIRWLMLHTADSAYDPNNKRLRQVKDQVLADSKYNPKILFQLLLDTAQFEFLLKEMFKQMLSEKQNKWESYKKEGSERMTELADVFSGVKPLTRVEKNEHLQAWFREIAKQIHSLNYDDSTAAGRKTVQLIQALEEVQEFHQLETNLQVCQFLADTRKFLHQMIRTINIKEEVLITMQIVGDLSYAWQLIDSFTAIMQESIRANPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVFYVRKVLQIIPESMFTSLAKIIKLQTHDIIEVPTRLDKDKLRDYAQLGARYEVAKLTNAISIFTEGILMMKTTLVGIIKVDPKQLLEDGIRKELVKRVAVALHKGLIFNSRAKPSELLPKLKDMAATMDGFHRSFEYIQDYVSIYGLKIWQEEVSRIVNYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFPPVDESMTFIGRLCREILRITDPKVTCYIDQMNTWYDMKTHQEVTNNHLFSEINDSLGTFGLNGLDRLLCFMIVKELQNFIRLYQRLILRDKSGQETLRALQKVVTPVKGIVANSAKIYSAAIAKTQKIWPAYLDAIMKVGQMQVLRQQIANELNYSCKFDSKHLAGALENFNEAILADIQAHYQDPSLPCPREDNTLLYEITAYLEAAGTHNPLNKIYITTKQLSFFPIVNFLFLVAQLPKLQYNKNLGMTCRKPADPIDWVPLVLGLLTLLKQFHSRYTEQFLALIGQFIRSSLEQSTSQKIPEMPADVVGALMFLEDYVHFAKLPRRVVEAHVPNFIFDEFRTIQ