Function
Regulator of meiotic chromosome structure and function, playing a role in sister chromatid cohesion, possibly via antagonizing the coh-3/-4 association with axial elements in nuclei during late prophase, cohesin association with chromatin, DNA double strand break repair and polar body positioning following meiotic divisions during oogenesis (PubMed:26841696). Regulates the morphogenesis and temporal assembly of axial elements to control the organization of meiotic chromosomes in pachytene nuclei and is also involved in meiotic chromosomal remodeling in late pachytene nuclei (PubMed:26841696). Required for the removal of the cohesin component scc-1 from mitotic chromosomes (PubMed:18202360).
Sequence
MSSDANSDDPFSKPIVRKRFQATLAQQGIEDDQLPSVRSSDSPDVPDTPDVPVNQLSSPPLSLPETLSEGNAETLQNLSDDSEPEMLSQSSTSSLNRRMEDSAIDPSRGTRKSQSRGFDYDPAGERTTAPVQKKKKDEIDMGGAKFFPKQEKKHVYTHKWTTEEDDEDEKTISSSSNRYSSRPNQPAVSARPRQPVYATTSTYSKPLASGYGSRVRHIKEANELRESGEYDDFKQDLVYILSSLQSSDASMKVKCLSAISLAKKCVSPDFRQFIKSENMTKSIVKALMDSPEDDLFALAASTVLYLLTRDFNSIKIDFPSLRLVSQLLRIEKFEQRPEDKDKVVNMVWEVFNSYIEKQEVGGQKVSFDMRKESLTPSSLIIEALVFICSRSVNDDNLKSELLNLGILQFVVAKIETNVNLIADNADDTYSILILNRCFRILESSSVFHKKNQAFLISHRSNILISSLAKFLQVILDRVHQLAEEEVKKYISCLALMCRLLINISHDNELCCSKLGQIEGFLPNAITTFTYLAPKFGKENSYDINVMMTSLLTNLVERCNANRKVLIAQTVKMVIPGHDVEEVPALEAITRLFVYHESQAQIVDADLDRELAFDEGGCGDEEEEEEGGDESSDEDGVRKDGRLDRNKMDRMDQVDVVHALQQVMNKASAHMEGSVIASYHALLVGFVLQQNEDHLDEVRKHLPGKNFQNMISQLKRLYDFTKATMAKRVESNSGFRAIERVIEYLERLE