Protein
Vacuolar protein sorting-associated protein 8 homolog
Organism
Drosophila melanogaster
Function
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis.
Similarity
Belongs to the VPS8 family.
Sequence
MSELKAPSLQSLLESERGSTDSLLAESLQLDFEDLDDAEFAIPPTDVLPTLEAVLSEFEADSDVASEFGMPVPHATPTPSIGEDSTIRTDGRGGGGSIMRYTLLHGISAQLSSAAERVNAGAASSCAVAAFIAIGTSHGHILNFDVTQTLRWAHQDKHGQGAVASLAFNADSTRLLAGFSRGLVAMLDTHTGDVLRELFDVITPNTGVLHVKWTSRSSLALCADAGGSVWSLSFTRKLGIRGCQSRCLFSGARGEVCAVEPLIMDSQGRHELDQYCIVALATLSKYFIVTVRPRLRVIKYHVLQGPPDCLPLLAWHLVLIQAADTSRSVDPVIVVGRGNQLFFHQLFVSNGRITLLYLRHVQLQGSLLSAHWLGPKCVASLDTAEILHLVDVRSSKELECMDMANAGLVYGSAQFKGLATGGNVSPAFALAGSNACYNSVVSRGTQLYVLGARSLHIIGVRTWSERISFLVKHHRWQEACQLALDGYIASVDRPRKRAQAKERIIMLFKEYIANSARAPEYCLGAIVNCLITVGELDLLWTQLWEKLHNSSTELFLQHISEHIEKETIHSVNPVISQALVDYWLEHSPAKLEQLILKLDWMCLDLNQVLKAVKKHRLFRAQIYLNTQALNDYTAALTELLPLVTPDETDLGNCLLVYVSSCLAGREYPSGEIPVELVHQVKHDVLRCLTSQHSKENAGDELPYPYLRALLKFDTRETLNVISLAFQEREFSNELGISHRKRIINLLLEIMSPENATWAEIGCLLNFIAQQISMQCLPRDRQLLERVLSHLAQEEIANESSRQHSERENAWHELLSSNCLAEISSDEEQLRLAEKAKCYCVVEYLLEKLERYDTILDSYIRNEARHETMFAYMERHVASPKRSIFRQLKRNLRELLTINAKETTRLLSLHYPEKINELLDNLRREENLLYLFLKCLNDRKSELEASQMELLLELYCKMESSSTVEEFLRSNSGYRLENAIAIAESHHLNRSVIYLYEKQESYAKAFELSMELLKSAAGEEAAKEAQTISALLARSVETLPAQELERCWFALLQYILPHQELQSITKSLLHEASQHIDLHNLVQLIMNTHNVSTSFGDIKDLLMGMLDSSRHKTEALRASAGALCQDLHLKFVKRYQHAHRGLWVTTTKCSMCRQRLYDHSQVLIFGGCGHGIHEQCMEESETQFEECPRCFTAIPDQSIGLPRPNKNLISISSSLEMGALQLKAPPRRFI