vps11

Vacuolar protein sorting-associated protein 11 homolog

952 amino acids

May play a role in vesicle-mediated protein trafficking.

Belongs to the VPS11 family.

108.28 kDa

MNNWKRFTFFDIETVKQVEKEDGSSLQKLSITCTTSGRGSLIIGDAEGFINFVDREFGISSFQAYQQSVSLIYQLKERNFLSSVGHDDIGGAAILKIWNLDKTDKNEQPICVRSIKLEKSVTVTCFTLLEDLSQIIVGLANGEIIIIRADIFRDKVIKQKIIKVPNDSPITGLGFFPTKSQQSASAGAVLFVVTTTHVITYHTAHKDQETIIDDEGGDIGSFLMSDDGSPIIARSDAIYFYNVDGRGPCFGFTGVKTKVLWFRSYLVVIGYDTNNTNALFPGAVVGGQNSIGGLGSQTGSIGSPSVMVQNTKNNVLNIYDLKNKYIGFTEKFDTVSHICSEWGSIFIFGADGKVFQLEEKDTQTKLETLFKKHSYQVAIDLAKSQHYDNSAIADVYREYGDRLYAKGDYDGAITQYLCTIGQLEPSYVIRKFLDAQRIHNLTSYIQALHEKNLATANHTTLLLNCYTKLKDVKKLDHFIMTDNGTFDVETAIKVCRQGGYFDRALFLASKHSRHDWYLKILLEDLNEYRKALDYIQTLDWEEADKNLKKYGKQLVSEIPEETTGVLMKLCTNYQPVQAFDSLTALNLNGLTISNQTTTTTTVTNVTNNNNQNNNSNNNNQNNNNNNNNNIGFKQKSAPEEFIHIFVSQADWLVKFLEYMVQQGNNESSLIYNTLLELYLRDDVNQTDDERIKRKAKAYEFLTNPKSKFDQDHALILVQVHNWKEGVLYLYEKLELFNEIIEYHMENNDYDGLIKACKRYGVKDPNLWVRALSFFSTNKQDCQDEIIEVLTNIDKENLIPPLLVIQILSQNKNTTLAVIKDYISRRLSQETQQIDKDYTQIRQYADETEKMRHEINELRTNSKIFQQTKCIACLLALDLPSVHFLCQHSFHQRCLGENERECPSCAGANKRIQEIKRSQADSANQHDQFFKLLRSSPDGFTTVSEYFGRGILN

VPS11

Vacuolar protein sorting-associated protein 11 homolog

941 amino acids

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

Belongs to the VPS11 family.

107.837 kDa

MAAYLQWRRFVFFDKELVKEPLSNDGAAPGATPASGSAASKFLCLPPGITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEKRDGGNPLCTRIFPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQILHKGNYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIAHWFRGYLIIVSRDRKVSPKSEFTSRDSQSSDKQILNIYDLCNKFIAYSTVFEDVVDVLAEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDSDGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTKLKDSSKLEEFIKKKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKILMHHIPEQTTQLLKGLCTDYRPSLEGRSDREAPGCRANSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEKDPQVKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQVISVCERHGEQDPSLWEQALSYFARKEEDCKEYVAAVLKHIENKNLMPPLLVVQTLAHNSTATLSVIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLRCSNDSFSVIADYFGRGVFNKLTLLTDPPTARLTSSLEAGLQRDLLMHSRRGT

Vps11

Vacuolar protein sorting-associated protein 11 homolog

941 amino acids

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (By similarity).

Belongs to the VPS11 family.

107.719 kDa

MAAYLQWRRFVFFEKELVKEPLGNDGAAPGAAPVSGSAASKFLCLPPGITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEKRDGGNPLCTRIFPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQILHKGNYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIVHWFRGYLVIVSRDRKVSPKSEFTSRDSQNSDKQILNIYDLCNKFIAYSAGFEDIVDVLAEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDSDGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTKLKDSSKLEEFIKTKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKTLMHHIPEQTTQLLKGLCTDYRPSLEGRGDREALSCRASSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEKDPQAKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQVIAVCERHGEQEPSLWEQALSYFARKEEDCKEYVAAVLRHIENKSLMPPLLVVQTLAHNSTATLSIIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLKCSNDSFSVIADYFGRGVFNKLTLLTDPPTARLTPSLEAGLQRDLLMHSRRGT

VPS11

Vacuolar protein-sorting-associated protein 11 homolog

932 amino acids

Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment.

Belongs to the VPS11 family.

105.713 kDa

MYQLRKFDFFEEKYGGKIPEDVTGDIQCCSSGRGKVVIGSNDGSVSFLDRGVKFDSGFQAHSSSVLFLQHLKQRNFLVTVGEDEQISPQQSGMCLKVFDLDKVQEEGTSSSAPECIGILRIFTNQFPEAKITSFLVLEEVPPILLIAIGLDNGCIYCVKGDIARERITRFKLQVDGRSAITGLGFRMDGQALLLFAVTPESVNLFSMQAQPPKLQTLDHIGGSVNTVTMSDRSELIVGRPEAVYFYEVDGRGPCWAFEGEKKFMGWFRGYLLCVIDDSKTGNTVFNVYDLRNRLIAYSIVVDKVSNMLCEWGNIILIKADKSLLCITEKDMESKLDMLFKKNLYTVAINLVQSQHADAAATANVMRKYGDHLYGKQDFDEAMLQYINTIGYLEPSFVIQKFLDAQRIYNLTNYLEKLHEKGLASKDHTTLLLNCYTKLKDVEKLNTFIRKEDGIGELKFDVETAIRVCRAANYHEHAMYVAKKAGKHEWYLKILLEDLGNYDEALQYVSSLEPSQAGVTIEQYGKILIEHKPKETIDILMRLCTEQGIPNGVFLSMLPSPVDFITVFVQHPHSLMHFLERYAEIVQDSPAQAEINNTLLELYLSRDLNFPSISLSENGLDKDLIDHSVAAAVSKADPEKKTNADSKDAMEKDCTERQQKGLELLKMAWPSDLEQPLYDVDLAVILCEMNSFKDGLLYLYEKMKFYKEVIACYMQNHDHEGLIACCKRLGDSSKGGDPSLWADLLKYFGEIGEDCTKEVKEVLTYIERDDILPPIIVLQTLAKNPCLTLSVIKDYIARKLEQESKIIEEDRRAVEKYQETTKNMRKEIEDLRTNARIFQLSKCTACTFTLDIPAVHFMCMHSFHQRCLGDNEKECPECAPEYRSVMEMKRSLEQNSKDQDLFFQQVKGSKDGFSVIAEYFGKGIISKTRDATS

vps11

E3 ubiquitin-protein ligase pep5

906 amino acids

Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase ypt7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion. Acts as component of the CORVET complex that is required for transport between endosome and vacuole. CORVET is an effector for the endosomal Rab GTPase ypt5. Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.

Belongs to the VPS11 family.

102.524 kDa

MSTFIKNWKRITLFQVKAIEENIDRLTSSFSSNGELVVFATAFGDVSIYNSSFKSLQSIKVEDESSIQQILWLDNKTFLLFSNVEGGTGTNSTVIIYAFSQADENEPPQFVLVTTHKFSINESPYPIIAVSQSPIDKTIACGFGGGLVSCYHGNPLRERGIKNSYSHNLGEPITGLTYLDDQSSVLFIATTNKTYSLSGKSLSCLDNTGVSLNCSSSCKTTPLQSREKNSSSFVCTRSSGLTFYDSKREKICFTFPGEKHYMTVMGSILALCYTPTLGTDSSTNEGLKKSFSSSSSIRKADASRNPAFPPRLLLVDLSRNLIVWEGHLKDVAVSILPLKHGFLVVTADDNVFELKRITLQEEISLLCQKMMYNLAISLAKKENMDIEFRESLMRDYASFLFRRGDFSASMDWYIRSIKSIDIPSVCLEFLKAQEIKQLIRLLEELIKTGLATSDHRLLLLSCYVEIHDSPSIRKLIDIGEIDFDQAFKICYDSNLLDEAKHLAIRFNNNERVLDVLVESEQYSEALRFFESLPPSNLLPLLLKYGRVLLDKLPEKTTNIFIQFYSNSHRGDLSTSESKGELKTAKSLRQTYLSLLPYAQVANFSLPPSLYEISPSQEENQRAALFSEDVSYTAPSPQTCFHIFLNHNSELISFLEGILPNASPNYKTLINTCLFEAYIRESFASSNVEKQEFWQEKSNSLLKKVEKNVDLNAVFLISQILGFDDGVRFVQGKSGQTLDIFRSFCQQNDIERALKMVRVHGPDQQELYIMMLNCFASLENVDSWYQDINEIVNIIVSQRLISPTQLLDILGKSVNIKLEHISDSMQSVLDNYRESISKQNEAIEMGKRDIEEITSQLSILRTRAFVVQESKCSTCGIDLELPMVHFRCGHSYHQRCVEDECIRCRWL