Protein
Vacuolar protein sorting/targeting protein 10
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Function
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
Similarity
Belongs to the VPS10-related sortilin family.
Sequence
MITRWLLITSFLALAILSLSSAAKKSEPEITPSSFDNEPFSLFYFEDTETILMNTRDGNLFRSFDGGKGWEQVDDPNGKMKKGVRSIWQHPFDKNRAYALGANRRHWVTKDQAKTWESFEVDGYAATQHEPLIFHGWDSSKVIFQSDECMGRFCIVKSYYSTDDFKTVSPLRVSAGGCAWAVGHPQFAEGLNLEDELRDRVLCIVPGLKVPSAHANRLVYSDDFFRSDAEGTELNIQQGRPVSGILSAAAVKKFFVTAAKSQGTNELALYVTLDTKAWHRADFGGHRVEQDGYTLLESTNYSMQVDVLTSPSSNTGILFTSNSNGTYFTRNVEHTNRDRFGHVDFEKIADIQGIVLVNTVKNWDKVGSENEKKVVSSISFDDGRTFQSLKVGDKQLHLHSVTTFANTGRVFSSPAPGLVMGVGNTGDHLKKYSEGSLYVSDDAGVTWRHALDGPFKYEFGDQGSVIMAVSDKGTTDEIQFSIDHGKEWHSTKLQHKIYPKLLTTTPDSTSLTFLLVGSEESSGTKHVVYSIDFRGLHERKCEKDDFEKWAARLNENGEPDCLMGHQQFFNRRKANADCFVDEEFKDPQPIFEPCKCSFEDFECDFNFVRSEDGKSCVPAAPLVPPVGRCQKQTDTFMGPSGWRLIPGNTCTREGGENLDKDVERPCKDVVSAPSHDKLMAQKQVFNDARQFSEQYYYLERQASSSGDDETVIMLTSEGEFWVSHDHGKNWEQPLKGVKIAAIVPHPYYSDGAFLLTRDKQAFWTVDRAYTFKSFEAPIPPNQEGLPVLSFHPQYKDWLIWTGAVDCAHGDCHSDAYFSKNRGENWDLLLRYVGKCEFESRENRPGSEKLIFCQQYENENKKNHLQLLSSENLFSDSHVHFNDAIRYATMSEYIIVASRDPDNPDSLVASVSVDGRTFARAEFPPNVDVPVKTAFTVLDSSTHAVFLHVTVSDVKGAEHGSIIKSNSNGTSYVLSLNAASRNEWGYVDFEKMQGLEGVAVVNIISNVEAVLKKGPTAKKLKTMITHNDGGQWMLLPPPAKDADGKNFGCSVKGGKGSGQCSLHLHGYTERRDPRDTFSSGSAIGLMMGIGNVGAHLSGKDEADTFMTRDGGITWKSVKKGRYMWEYGDSGSVIVIVPELRPTKVLYYSLDEGDNWEPYEFSEVEMHIYRLSTVPSDTSKNFLLWGKEVESNRLATINVDFSGLRKKSCNLVENGQESDDYYLWEPKHPFQEDNCLFGHVEQYHRKKPSSQCWNNWREPHVHSIGRNCTCTRADYECNYNYEPQNDGSCALVPGLPKPDALAVCREDPDRVEYWEPTAYRRIPQTTCAGGLILDHVVSKPCPSKEKEYEKKHGISGTGLFFAIMIPIVAAAGVGYYVYAKWDGKFGQIRLGENAGTYEGLLSRESPIVTVPIAVIAGIVAVIRALPLLAMSLWRSASGYVRLGRNRAYSRPYASRGSFAARRGDYTSVVDDEDELLGVDDAEIDEDDEL