vps-41

Vacuolar protein sorting-associated protein 41 homolog

901 amino acids

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:26783301). Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine (PubMed:24501423). May mediate the tethering of autophagosomes with lysosomes (PubMed:24374177). Has a role in the negative regulation of apoptosis (PubMed:15837622). Required for uptake of exogenous dsRNA which is used in experimental RNA silencing (PubMed:16862146).

Belongs to the VPS41 family.

102.579 kDa

MDETHENEASDSFDPVFENSYHDDVTFNTEDDDEPPLEPRFKYERLKGEETLPFMKTATFTSIDLHDKFIAIGTATGLIYILDHHGYGNFDSVPPLKPHRCAVSKVKFDETGSYVLSCANDSKIVVSGVGNDKLCCTINIQVMPKSIYFSPDFIRQQSGHCFIMGERNLVLYEKRMFQYKASSLYSGSERDGFIHCCSWNENLIAFTNDTGTRVYERGAERIITSVQPSHDVDRVRSSRSPPKHTWMPENNLVIGWADTVTILKIRDDDGVKKGEVHHIFHVSMFICGISYIPESGIDNMELFLVGLQLEGEDFDDCASVISTVTTLTALESSACTILKTSVIRPLGLKEFELQSEDMIESVKLSNHTLPYMIHGLGIPYLATYFILTTKHIIMAVPYGPEDGIRWRLKYKLYDEALDMAKHNADLLSKTDLSPKKVGRMIIEGYLTGKRARAAASRLPLICGECKEEWEWAVNQFEEVKLCTLLAEVLPDGTPTLDPECYQKVLIACLFNNVKQFRKLVQTWSPDLYMTSFIIDRTQWRIQQISKSGNLADVDETERVLMDALAHLYLYERKYESALKILMSCQDFQIFNVIDKHQLFDLVKDQITELMNINSERALRLLLDNADSVEPSFVMEKIGRQPKLQLAYLTKLMSRNEGTEFADKAVQLYAEYDQKKLLPFLRKNANYNVNKARKLCSDKGYIEETIYLLAKSGNHYDAVKMMVREYRNMEKVIDYCKDQNDPDLWIHLLGVVAEFPAHFSQLIIEASNCLDPLLIMDKLPDDSDIPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQGLISAADESVSVNIVSRCSLCAQIIINSNQETTKKFSDIKVFKCGHIFHLACSTSEMERRQSIEEGLCIACSDQIELINV

vps-41

Vacuolar protein sorting-associated protein 41 homolog

898 amino acids

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine. May mediate the tethering of autophagosomes with lysosomes. Has a role in the negative regulation of apoptosis. Required for uptake of exogenous dsRNA which is used in experimental RNA silencing.

Belongs to the VPS41 family.

102.403 kDa

MDESNDKENEFGDSFLEDSGDITRTTEDEDEAPLEPRFKYERLEGESTLPFMKTATFTSIDLHDKFIAIGTASGLIYILDHHGYGNFDSVPPLKPHRCAVSKLKFDETGSYILSCANDSKLVVSGIGNDKLCCTVNIQVMPKSICFSPDFIRQQSGHCFIMGERNLVLYEKRLFQYKASNLYSGSERDGFIHCCSWNDNLIAFTNDTGTRVYERGTEKILTSVQPTHDVDRVRSSRCPPKHMWMSENTLVIGWADTVTVLKIKGNEGMRKGEIHHIFHVSMFISGISYLPKNGSDYELFLVGLQMEGEDFDDCASVMSTMTTLTAMESSATATLKTCVIRPLGLKDYELQSEDEIVNIRLSTHTLPYMIHGLGIPYLSTYFILTTKQIIMAVPYGPEDGIKWRLQYKLYTEAFEMAKEHADMLAKTDVSPKKVGRKIIEGYLESKKARVAASWLSSICGDCKEEWEWAVDRFHDAKMSTLLGDVLPDSKPRLDPSAYEKVLLASLFNNVKLFRRLVQTWSPDLYMTSTIIDQTQWRIQQISKSEDIEDVEEVEKILMDALAHLYLYERKYESALKILMICQDFQIFNVIDKHQLFDLVKDQISDLMNINSERALRLLLDNADSVEPSFVMAKINGQPKLQLAYLTKLMSRNEGIEFADKAVQLYADHEKKKLLPFLKKNVNYNVTKARKLCSDRGFVEETIFLLAKSGNHYEAVKMMVREYKNIEKVIAYCKDQNDRDLWIHLLEVVADFPTHFSQLIIEASNCLDPILIMDKLPDDVDIPNLSEALEKLLTDFTNYVELQQCCYDSTLNDLHVLTNNLMLASDKSVSVSLMTRCSLCSQVIMNTGQDMIPRKFNDIKVFKCGHIFHLTCSASEIDRRQMIEDGICIACSDNSDHVNV