vps-16

Vacuolar protein sorting-associated protein 16 homolog

858 amino acids

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine. The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for recruitment of vps-33.1 to the HOPS complex. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with vps-33.1 but not vps-33.2.

Belongs to the VPS16 family.

96.378 kDa

MKESTRTSTPSSGAKPKGDREICLRPSSSVFLGDQQLYFTQEYLATNSLNMKYVVYFAACQFSGPIAVIYAAPKSWFIWIRTISGRILKRDLPCTDPVFIDWTRAHCLLVLSKNGRAQVLSSIGEKVSEVFFDNQVSDVHECRTFATSRGDSGIAVMDVDGQVAVVNSVSEPVIWSMRPPYSELPTAWTAFQPHSQLTHILLIFEAVFLMGCQGESLQVQNHASVWVDSSTKYVKCVVDDARSRIAMMTENGKIQIVSIDLSTCFCTVEVTEHEIGKCINFGWVGNSVVFVQMSSSLTVFVNVSARRKPGDEVRFMSIKMTANARISVEPDGIRLFESTRVEFVEAASREKIAVLNRSLNEDGAYLYKAAQEMEQGTGHNSFAASTVIQDMYKAIDDCISTACDTWQPEEQKLLLKAARFGMAYTNTTPDTTKLMRAIKEIRVLNELRMVRTGIPLTHRQYRIIGDTCIINRLIDMGSYSVAIKVAQWLGGENCESVDRVLLEWVRRSISKVSRSNMKMDQPALEALDEKISAKLLQFPHVSMADAARRAIEAKLPELARLFIRRETDDESHVAVLLQLNDVSAALTKAAASQRPQLIHQVVRHLMTSESRSSYELAISRIPLAQCLYQDLVRQEGETRGISSRQMLALLEQASDFERQTLFHFDVAEIERNPSERLNALRRAKDAAKSMGDKAIEEILNDVSAFAPLQIQRGQADMSVRDTIIEIADDTAKVAQLKQQARLNDKQVLLWTIEGLAKKGKMEQLFDLAQKRSPIGYAPFVKACVRYKRNEEVNKYFAKANGYSDLVAANLAKKNYVDAAKLAYDRRDREVLHAIHMKSHDDPVQCPRVKQLLNSMDQA

vps-16

Vacuolar protein sorting-associated protein 16 homolog

852 amino acids

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:26783301). Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine (PubMed:15843430, PubMed:24501423, PubMed:25273556). The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for recruitment of vps-33.1 to the HOPS complex (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with vps-33.1 but not vps-33.2 (By similarity).

Belongs to the VPS16 family.

95.843 kDa

MGESHAPSKPKLDGELCLRPSSSVFLGDQQLYFTQEYLRTNSLNLKYVVYFTACQFSGPIAVAYSPRPASWYIWIRTISGRILKRDMAFNEPVFMEWTRAHCLLVLNKAGRAHIFSSLGEKISEVIFDSQMSDVHECRTFATSRGDSGIAVMDVDGQVSVVNSVSEPVIWSMKPPYSEMPTAWTAFQPHSQLTHILLIFEAVFLMGCQGESLREQSHAASWVDSNTKYVKCVVDDARSRIAMMTESGKIQIVSIDLSTCFCTVEITDHDIAKCINFGWVGNSAVFVQMSPSLIVFVNVSARRKPGDEVQIYEKMTANAKISIEPDGIRLFESTQVEFVEAASREKIAVLNRNPNEDGAHLYKAAQEMSQGTGHNSFAASTVIQDLYKAIDDCISTACDTWQPEEQKLLLKAARFGMAYTNTTPDTTKLMRAIKEIRVLNELRMVRTGIPLTHRQFRAIGETCVINRLIDMGSYSVAIKVAQWLGGETSENVDRVLLEWVRRSISKVSKSNMKMDQPALEALDEKISAKLLQFPHVSIADAARRAIEAKLPELARLFIRRETDDANHVAVLLQLNDVSAALQKASASQRPQLIHQVVRHLMNSESRSSYELAISRIPLAQCLYQDLVRQEGETRGASSRQMLALLEQASDFERQTLFHFDVAETERNPDERLNALRRAKDAAKSMGDKAIEEILNDVSAFAPLQIQRGQADMSVRDTVIEMAHDTAKVAQLKQQARLTDKQVLLWTIEGLAKKGKMEQLFDLAQKRSPIGYAPFVKACVRYKRLDEIKKYFAKVNGYPDLVAAHLAMKNYVEAAKLAYDRRDRDVLHAVHMKSHEDPTQCPRVGQFLRSLDQN