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vosA

Gene
VOSA
Protein
Spore development regulator VOSA
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
501 amino acids
Function
Component of the VELB-VOSA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (By similarity). The complex binds DNA through the DNA-binding domain of VOSA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity). Appears dispensable for the development and pathogenicity (PubMed:24632440).
Similarity
Belongs to the velvet family. VosA subfamily.
Mass
54.285 kDa
Sequence
MSLPSIGSVGSDRMAAYMHGQQVYTGQFGDPNLTPPQAETQMSAQASAQAVGQEPEPDYKLVIRQEPQRARVAQGKEKGTDRKPIDPPPIVQLIRTARSDPAQIYLQSPYYFMACTLIKGSDDDPDPNPNSMLGTLVSSLHKLRDLNNEDGGFFIFGDLSIKIEGVFRLQFTLFQMKDSTCVFLDSATSQPFTVYPQKNFEGMAESTFLTRSFSDQGVRLRVRKDSRAMTTRKRNHQHAEVAKKHSEWDRKQTSAVSRHSSINENDSTPTDTRGLASFAGAGSSGYYDQHRSHYGETYGHDTYYGGARSVKRARHEVSPGQYALPDLPQQAYATRQPSFSDSVASMTMPPVTTAAPSLAGINPMSSHHGYTGSAHPGFAPHRINTQVGGSHLAPQPHSAIGSVNQGYQSPSTHHQPHPHTAHPAGGQAYPSPSPRQSPGTAPNYHYGSHHSQQTPVSLGLETYTSAGVVGMPGPGQLVGTSAPSPHLGQGYRHGMINEPGA

Gene
vosA
Protein
Spore development regulator vosA
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
430 amino acids
Function
Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (PubMed:17912349, PubMed:21152013, PubMed:23049895, PubMed:24391470). Controls primarily the late process of sporulation including trehalose biogenesis (PubMed:17912349). The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (PubMed:24391470). The vosA-velB complex binds to the beta-glucan synthase fksA gene promoter in asexual spores for repression (PubMed:25960370).
Similarity
Belongs to the velvet family. VosA subfamily.
Mass
47.33 kDa
Sequence
MSAANYPDPSLPRPSTSDDFELIVRQNPNRARVAGGKEKERKPVDPPPIVQIRVREEGTYLAQHYLQSPYFFMSCSLYDAQEDAPASIPPSTALTGTLVSSLHRLKDVDNTDGGFFVWGDLSIKVEGDFRLKFSLFEMRKTDVVFLKSIVSERFTVSPPKSFPGMAESTFLSRSFADQGVKLRIRKEPRTLIKRTAPRPEEYPQAAIPRSPSDRTAMQIPGSSYPAPPYQPTSRDYSYYAPVKRQRTSVDYGARGMYDADGRMRQMETYPQTATLYGQPGGYPTPMMGYPSGHGGVPDYAMSYGLPPSAQVPQMQDPAAQSRSSQQATMQSLGMVNPPGTPTPDSARAMMQQAYPRPQYSASTAVLPPLQQSRNYPQGTNGATRGYYEQSPQATPILPSQPLGTSEAERYGVPPGHTGYDHTGSANGTPR

Gene
vosA
Protein
Spore development regulator vosA
Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)
Length
390 amino acids
Function
Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (PubMed:23264641). The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity).
Similarity
Belongs to the velvet family. VosA subfamily.
Mass
42.821 kDa
Sequence
MLNNTSSDFDLIIRQQPNRARVAGGKEKEERPVPVAPSTALAGTLVSSLHRLKDVDNSDGGFFVFGDLSVKIEGEFRLKFTLFEMRKDRVSYLKTVISERFTVSPPKSFPGMMESTHLSRSFADQGVKLRIRKEPRTMLKRSTRPDEFHQPVPTRSPERQSVQIPPSSSYGGYPPAARDYGYYGQQPPVKRHRTSIDYGRQQGLYDVDGRMARQMDPYGQPTAAMYAGQPAAYQTPAAMQTYNTGQVVPDYTAMYPGMQASAGMQASAPMSQIPDPTGQSRSSQQQQAAVGQLMAMNQPGTPTPDSTGAMMAQGYARSGYPPSSTILPPLQRSRDYPQGTNGSARAYFDQTPQANTPILPSQMVNEGDRFSSVTGPTTFNHPDSPNGTPQ

Gene
vosA
Protein
Spore development regulator vosA
Organism
Cochliobolus sativus (strain ND90Pr / ATCC 201652)
Length
348 amino acids
Function
Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (By similarity). The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity). Regulates spore viability, trehalose accumulation, and tolerance to thermal and oxidative as well as ion stresses (PubMed:26399184). Positively regulates conidial pigmentation and pathogenicity on barley (PubMed:26399184).
Similarity
Belongs to the velvet family. VosA subfamily.
Mass
39.18 kDa
Sequence
MAFSYNYSLQASYPSQRAYVPYQQTQVPTPSPIYSLPITNTTTSGALSPSSCFLSVRQQPKEALVTVKGKEKFRKPLDPPPMLELKVSSDIDPSQQFLQNPYLFVSVSLYKHDKDEPIEGTPFDVLAGTLVSSLHRLKDVNNKDGAFFIFGDISIKVQGTYRLRFTLYELQPSYFTLSDLEQHKDLERYQGAALDPPEYGTYQCLGHVLSDKFNVVLPKDFKGLEESTYLSRAFSDQGVRLRLRKEARGMMSNKRSISGSGDLTSDQSQQQQQQQPLAKKRREDSVESANPSSLMSGFYQNVSPFVNTPYLQSQGLQGQTLQNQGLQAPVRHDTSYAWNLAYDPSFMG

Gene
vosA
Protein
Spore development regulator vosA
Organism
Beauveria bassiana (strain ARSEF 2860)
Length
273 amino acids
Function
Component of the velB-vosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (PubMed:26243054). The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity). Positively regulates the expression of wetA and represses abaA and brlA (PubMed:26243054). Acts as a crucial regulator of both conidiation capacity and conidial quality (PubMed:26243054). Responsible for the synthesis and accumulation of intracellular trehalose (PubMed:26243054).
Similarity
Belongs to the velvet family. VosA subfamily.
Mass
31.174 kDa
Sequence
MARHKTSDIMLPAAWRIPWDRQLDQHMARVIKAMAQINFASNMHHNLFMFTTREGLLHRNRMLSSSTTQELQSTQPIAVRQQPRAARACGFGDRDRRVIDPPPIVQLRIDGPGLSEEERRAYLRYPNYVMNCSIWDESGTRDASYMPDEYNHQRRLMGSLVGTPFVGDDDQNQEGCFFCFSDLSCRTPGAFRLKFTLIMIDPARASILRHFPTLTEIKTDIFQVYSAKEFPGMVASSSLAKKLKEQGCIISIKKGNERARPRGADGRSDDEDD