vlp25

Gene

vlp25

Protein

Variable large protein 25

Organism

Borrelia hermsii

Length

362 amino acids

Function

The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time. Switching between these genes is a mechanism of host immune response evasion.

Similarity

Belongs to the variable large protein (Vlp) family. Alpha subfamily.

Mass

36.469 kDa

Sequence

MRKRISAIINKLNISIMMMIVVLMIGCGQQAVEAGKDGAAAATGGRSLSEVLMEVGKSAENAFYSFMALVPDTLGLRVTKDTKKNEVGGYFNSLGGKLGKASDELEEVAKKSEVEGAKDGPIAVAIRAAVDTAKTTLSTLKEHLESLKGIGDDDKVGEATSNQNGVAASTDELKGAFKALKGIVDTAGKEGVAKPKAGDTAVKIGNADNKDGAKVLAAAANAGRAVGDKAAAIVSAVSGEEMLASIVASQEGDADAALAADATAQTSALKFARGGGNAGQLAKEAAKAAAVAGGIALRSLVKGGKLAANNNDDDKVVQSAGVTAVNKLLVAVEGIIKKTVKNVLEKAKGEIDKARAPKATGQ

Protein

Variable large protein 25: vlp25