virB11

Type IV secretion system protein VirB11

362 amino acids

The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. Virb11 is essential for pathogenesis in mice but is not required for intracellular survival.

Belongs to the GSP E family.

40.885 kDa

MMSNRSDFIVPDEAAVKRAASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMGERIQIVRPPACEHGTISVTIRKPSFTRRTLEDYAQQGFFKHVRPMSKSLTPFEQELLALKEAGDYMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDHPNHVHLFYPSEAKEEENAPVTAATLLRSCLRMKPTRILLAELRGGETYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQLPYEIIRRLLYLVVDVVVHVHNGVHDGTGRHISEVWYDPNTKRALSLQHSEKTQ

virB11

Type IV secretion system protein VirB11

362 amino acids

Belongs to the GSP E family.

40.885 kDa

MMSNRSDFIVPDEAAVKRAASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMGERIQIVRPPACEHGTISVTIRKPSFTRRTLEDYAQQGFFKHVRPMSKSLTPFEQELLALKEAGDYMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDHPNHVHLFYPSEAKEEENAPVTAATLLRSCLRMKPTRILLAELRGGETYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQLPYEIIRRLLYLVVDVVVHVHNGVHDGTGRHISEVWYDPNTKRALSLQHSEKTQ

virB11

Type IV secretion system protein VirB11

362 amino acids

Belongs to the GSP E family.

40.855 kDa

MMSNRSDFIVPDEAAVKRAASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMGERIQIVRPPACEHGTISVTIRKPSFTRRTLEDYAQQGFFKHVRPMSKSLTPFEQELLALKEAGDYMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDHPNHVHLFYPSEAKEEENAPVTAATLLRSCLRMKPTRILLAELRGGETYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQLPYEIIRRLLYLVVDVVVHVHNGVHDGTGRHISEVWYDPNTKRALSLQHSEKAQ

virB11

Type IV secretion system protein VirB11

361 amino acids

The VirB system could be required for the establishment of the replication niche in the host.

Belongs to the GSP E family.

40.727 kDa

MMSNRSDFIVPDEAAVKRAASVNFHLEPLRPWLDDPQITEVCVNRPGEVFCERASAWEYYAVPNLDYEHLISLGTATARFVDQDISDSRPVLSAILPMGERIQIVRPPACEHGTISVTIRKPSFTRRTLEDYAQQGFFKHVRPMSKSLTPFEQELLALKEAGDYMSFLRRAVQLERVIVVAGETGSGKTTLMKALMQEIPFDQRLITIEDVPELFLPDHPNHVHLFYPSEAKEEENAPVTAATLLRSCLRMKPTRILLAELRGGEAYDFINVAASGHGGSITSCHAGSCELTFERLALMVLQNRQGRQLPYEIIRRLLYLVVDVVVHVHNGVHDGTGRHISEVWYDPNTKRALSLQHSEKT

virB11

Type IV secretion system protein VirB11

356 amino acids

The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent VirB-independent mitogenic activity. These changes of HEC require the T4S coupling protein VirD4 and at least one of the effector proteins BepA-G. Altogether with VirB4, may be implicated in providing the energy, via hydrolysis of ATP, for the assembly of secretion system and substrate transport.

Belongs to the GSP E family.

39.721 kDa

MNQNLHTLSDETVAIVLTKLEPISTFLKDENLFEIVINRPYQVMTEGVEGWKTIETPALSFNELMGIAKVVASYSKQNISEKNPILSATLPGNERIQIVIPPAVEKNTISMTIRKPSSRSFSLEDLANKGLFSVCEQVSFTPLNNYLSHLSELKHIDHDLVRAYAKKDFVFFLNQAVQCQKNILIAGKTGSGKTTLSKALIAKIPDDERIITIEDTPELVVPQPNYVSMIYSKDGQGLASVGPKELLESALRMRPDRILLQELRDGTAFYYIRNVNSGHPGSITTVHASTALAAFEQMTLLVKESEGGGDLERDDIRGLLISMIDIIIQCKRIEGKFKVTEIYYDPFKQRNIFGGN

virB11

Type IV secretion system protein VirB11

356 amino acids

Component of the type IV secretion system VirB/VirD4 which could be a major virulence determinant for subversion of human endothelial cell (HEC) function. Altogether with VirB4, may be implicated in providing the energy, via hydrolysis of ATP, for the assembly of secretion system and substrate transport.

Belongs to the GSP E family.

39.615 kDa

MNQNLHKLSNETVAIVLTKLEPISAFLKDKSLFEIVINRPYQVMTEGIEGWKTIEAPALSFDELMGIAKVVASYSKQKISDKNPILSATLPGNERIQIVIPPAVEKDTISMTIRKPSSRNFSLEELANKGLFSVCEQVSFTPLNDYQSRFSELKHIEHSLATAYSNKDFVSFLNQAVKCQKNILIAGKTGSGKTTLSKALIAKIPDNERIITIEDTPELVVPQPNYVSMIYSKDGQGLASVGPKELLESALRMRPDRILLQELRDGTAFYYIRNINSGHPGSITTVHASTALAAFEQMTLLVKESEGGGDLERDDIRGLLISMIDIIVQCKRVEGKFKVTEIYYDPFKQRNIFGGN

virB11

Protein VirB11

344 amino acids

Required for the transfer of T-DNA to plants. Couples energy, by means of ATP hydrolysis, to T-DNA transport.

Belongs to the GSP E family.

38.14 kDa

MEVDPQLRILLKPILEWLDDPRTEEVAINRPGEAFVRQAGAFLKFPLPVSYDDLEDIAILAGALRKQDVGPRNPLCATELPDGERLQICLPPTVPSGTVSLTIRRPSSRVSSLKEVSSRYDAPRWNQWKERKKRHDQHDEAILRYYDNGDLEAFLHACVVGRLTMLLCGPTGSGKTTMSKTLINAIPPQERLITIEDTLELVIPHENHVRLLYSKNGAGLGAVTAEHLLQASLRMRPDRILLGEIRDDAAWAYLSEVVSGHPGSISTIHGANPVQGFKKLFSLVKSSAQGASLEDRTLIDMLATAVDVIVPFRAHGDIYEVGEIWLAADARRRGETIGDLLNQQ

virB11

Protein VirB11

343 amino acids

Required for the transfer of T-DNA to plants. Couples energy, by means of ATP hydrolysis, to T-DNA transport.

Belongs to the GSP E family.

38.009 kDa

MEVDPQLRFLLKPILEWLDDPKTEEIAINRPGEAFVRQAGIFTKMPLPVSYDDLEDIAILAGALRKQDVGPRNPLCATELPGGERLQICLPPTVPSGTVSLTIRRPSSRVSGLKEVSSRYDASRWNQWQTRRKRQNQDDEAILQHFDNGDLEAFLHACVVSRLTMLLCGPTGSGKTTMSKTLISAIPPQERLITIEDTLELVIPHDNHVRLLYSKNGAGLGAVSAEHLLQASLRMRPDRILLGEMRDDAAWAYLSEVVSGHPGSISTIHGANPIQGFKKLFSLVKSSVQGASLEDRTLIDMLSTAIDVIIPFRAYEDVYEVGEIWLAADARRRGETIGDLLNQ

virB11

Protein VirB11

343 amino acids

Required for the transfer of T-DNA to plants. Couples energy, by means of ATP hydrolysis, to T-DNA transport.

Belongs to the GSP E family.

38.009 kDa

MEVDPQLRFLLKPILEWLDDPKTEEIAINRPGEAFVRQAGIFTKMPLPVSYDDLEDIAILAGALRKQDVGPRNPLCATELPGGERLQICLPPTVPSGTVSLTIRRPSSRVSGLKEVSSRYDASRWNQWQTRRKRQNQDDEAILQHFDNGDLEAFLHACVVSRLTMLLCGPTGSGKTTMSKTLISAIPPQERLITIEDTLELVIPHDNHVRLLYSKNGAGLGAVSAEHLLQASLRMRPDRILLGEMRDDAAWAYLSEVVSGHPGSISTIHGANPIQGFKKLFSLVKSSVQGASLEDRTLIDMLSTAIDVIIPFRAYEDVYEVGEIWLAADARRRGETIGDLLNQ