Protein
Developmental and secondary metabolism regulator veA
Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)
Function
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:20543063). The velvet complex acts as a global regulator for secondary metabolite gene expression (PubMed:22439693). Controls the expression of the penicillin gene cluster (PubMed:20543063, PubMed:22439693). Positively controls the expression of the class V chitinase chiB1 (PubMed:21816879). Positively controls the expression of the transcription factor atfA (PubMed:25557366). Required for cell wall integrity and controls hyphal branching (PubMed:20543063).
Similarity
Belongs to the velvet family. VeA subfamily.
Sequence
MANRPSLMPPHNETEHSVSRITREGKQLTYKLSVMQQPERARACGAGAKSSADRRPVDPPPVVELRIFESDPANDTQKTDITFAYNANFFLYATLETARPIAHGRVGGPQSCPVLTGVPVAGVAYLDRPSQAGYFIFPDLSVRHEGRYRLSFHLYEEIKDAKDADKDSTLPLPNQIPLSATSKPGIPQAFLHFRLEVKSVPFTVYSAKKFPGLATSTSLSRIIAEQGCRVRIRRDVRMRRRGDKRDEDYEFGEERAAAYARSSDRFTTPDRYAASMDRPRSNSNGSNIESPYGFVPPDRRPSAPDYGFQCPQPYQRPMPPAPMSHSQTPSYQSHLSFGSTPSHYPAPHMPPTPPPVAPQGIYSPQHAYAQIRHPSNGSEYEGTPIAYPAPQIPVERGGYPKPPMSSYAMDPPKPNSYMDPRMPEPSLYPSTPNVPVSRPQTPNLPAMPPPKPLSNDYANHVVPSVECTSPGGSGGGGYDNVRGKRMVYQTGPTYGKRSHEDTFGLDDRSMQNGMRPDTEPYPAYRDFSGESRAALMAEMGIQLSYKRANGKIVMKAPPSST