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vegt-b

Gene
vegt-b
Protein
T-box protein VegT-B
Organism
Xenopus laevis
Length
455 amino acids
Function
Transcription factor required for both mesoderm and endoderm formation in the embryo; signaling determinants and concentration levels may determine which germ layer is formed. Acts together with beta-catenin to activate genes that are responsible for mesoderm induction including wnt-8, eomes t/bra, siamois, mix1 and sox17. Directly binds to promoter DNA. Patterns the mesoderm along the dorsoventral and posterior axis. Activates siamois gene transcription when alone or in combination with beta-catenin, but inhibits siamois transcription in combination with pou5f1.1/oct-25.
Mass
51.963 kDa
Sequence
MRNCCRERGFSVGRLEPETSFSCASDVKSSPDMDSVSSQDSLYLPNSIGASLEDQNLWTQFHQEGTEMIITKSGRRMFPQCKIRLFGLHPYTKYMLLVDFVPLDNFRYKWNKNQWEAAGKAEPHPPCRTYVHPDSPASGAHWMKDPICFQKLKLTNNTLDQQGHIILHSMHRYKPRFHVVQSDDMYNSPWGLVQVFSFPETEFTAVTAYQNEKITKLKINHNPFAKGFREQERSHKRDDVLKTLQQSPSKSQKRKKWEDSPEADISDFPKATRIKEESIMDPAGVYQNWVSDHEANQGLTPHSPESEGVNQEQQVPTSSSNFYIKSQYRRSSQHLSSPYDLGEPSSRRLTPDVATVPDSDPDSLAVLHVIPTQNSAQERTCSMNFSMETPMKQPLRGAIYSPYGTEQWMVPAQGPYQPVSYTAYPTDLSAQGAVAHPHSGMSDWSQYSLFPYSCW