Protein
Valine dehydrogenase
Organism
Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858)
Function
Oxidative deamination of branched-chain amino acids. Oxidizes L-valine and L-alpha-aminobutyric acid efficiently, and L-alanine and L-isoleucine less efficiently. D-valine and L-glutamate were not substrates for the enzyme. The catabolism of valine is the major source of fatty acid precursors for macrolide biosynthesis and a vital source of antibiotic precursors.
Similarity
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Sequence
MTDVTGAPADVLHTLFHSDQGGHEQVVLCQDRASGLKAVIALHSTALGPALGGTRFYPYANEAEAVADALNLARGMSYKNAMAGLEHGGGKAVIIGDPEQIKSEELLLAYGRFVASLGGRYVTACDVGTYVADMDVVARECRWTTGRSPENGGAGDSSVLTSFGVYQGMRAAAQHLWGDPTLRDRTVGIAGVGKVGHHLVEHLLAEGAHVVVTDVRKDVVRSLTERHPSVVAVADTDALIRVENLDIYAPCALGGALNDETVPVLTAKVVCGAANNQLAHPGVEKDLADRGILYAPDYVVNAGGVIQVADELHGFDFDRCKAKAAKIYDTTLAIFARAKEDGIPPAAAADRIAEQRMAEARARR