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vapC11

Gene
vapC11
Protein
Ribonuclease VapC11
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
134 amino acids
Function
Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Its toxic effects on cell growth and colony formation are neutralized by coexpression with cognate antitoxin VapB11 (By similarity).
Similarity
Belongs to the PINc/VapC protein family.
Mass
14.651 kDa
Sequence
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAAGIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Gene
vapC11
Protein
Ribonuclease VapC11
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
134 amino acids
Function
Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in E.coli and M.smegmatis inhibits translation, cell growth and colony formation. Its toxic effects on cell growth and colony formation are neutralized by coexpression with cognate antitoxin VapB11; the effect on translation has not been tested but is probably also neutralized.
Similarity
Belongs to the PINc/VapC protein family.
Mass
14.651 kDa
Sequence
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAAGIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR