Function
Has a role in non-canonical Wnt/planar cell polarity (PCP) signaling; can recruit dvl/dsh and prickle from the cytoplasm to the plasma membrane. Acts in a PCP complex to regulate the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Regulates convergent extension cell movements in both dorsal mesoderm and neural tissue during gastrulation, without affecting cell fate. Regulates neural fold closure during neurulation (PubMed:11867525, PubMed:11780127, PubMed:12421719). May be required for cell surface localization of fzd3 and fzd6 in the inner ear (By similarity).
Sequence
MDNDSQYSGYSYKSGHSRSSRKHRDRRERHRSKSREGSRGDKSVTIQAPGEPLLDNESTRGEDRDDNWGETTTVVTGTSEHSISHDDITRITKDMEDSAKLDCSRHLGVVIGGALALLSFLTPIAFMLLPQILWREDLEQCGTACEGLFISVAFKLLILLLGSWALFFRRPKAFFPRVFVFRALLMVLVFLLVVSYWLFYGVRILESRDKNYQGIVQYAVSLVDALLFVHYLAVVLLELRQLQPQFTIKVVRSTDGASRFYNIGHLSIQRVAVWILENYYHDFPVYNPALLNLPKSILSKKMSGFKVYSLGEENTTNNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRKARLVVAVEEAFTHIKRLQDEDQKNPREIMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILHHLEFCITHDMTPKAFLERYLGPGPTIQYHKDRWLAKQWTLVSEEPVTNGLKDGVVFVLKRQDFSLVVSTKKIPFFKLSEEFVDPKSHKFVMRLQSETSV