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vPK

Gene
vPK
Protein
Viral protein kinase
Organism
Human herpesvirus 8 type P (isolate GK18)
Length
444 amino acids
Function
Serine kinase that plays a role in viral gene expression, viral DNA replication and encapsidation, and nuclear egress of virions. Regulates host transcriptional activity through interactions with RNA helicase and c-Jun N-terminal kinase (JNK) and viral transcriptional activity through interactions with the viral protein K-bZIP/K8 (PubMed:17108053). Induces host chromosome condensation and phosphorylation of histone H3. Phosphorylates the DNA polymerase processivity factor hence modulating its processivity function. Inhibits the host Wnt signaling pathway via direct interactions with beta-catenin/CTNNB1 while the kinase activity of vPK is not required for this inhibitory activity.
Mass
50.335 kDa
Sequence
MRWKRMERRPPLTPLRRSRTQSSGGGLTICPRCALKLPKATRISERPWASTWQLNQHIQVSKTKKATAYLKAPREWGQCTHQDPDWSKRLGRGAFGIIVPISEDLCVKQFDSRREFFYEAIANDLMQATRERYPMHSGGSRLLGFVQPCIPCRSIVYPRMKCNLLQLDWSQVNLSVMAAEFTGLMAAVSFLNRYCGMVHCDVSPDNILATGDLTPMNPGRLVLTDFGSVALHSGSKWTNLVVTSNLGFKQHCYDFRVPPKLICKHLYKPSCVLFQCYLSSLGKMHAQVLDQPYPISPNMGLTIDMSSLGYTLLTCLELYLDLPLNNPLKFLGSATRDGRPEPMYYLGFMIPRVVMTQILSAVWTMTLDLGLDCTGKAQAIPMRQEHQLAFQKQCYLYKANQKAESLANCSDKLNCPMLKSLVRKLLERDFFNHGGHPHTRGLVF