Protein
Lissencephaly-1 homolog
Organism
Nematostella vectensis
Function
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.
Similarity
Belongs to the WD repeat LIS1/nudF family.
Sequence
MVLTPRQKEELNKAIADYLHQCGFEDTLNAFKQDANMPGELDKKYTGLLEKKWTSVIRLQKKVMDLETRLSEAEKEVHHGGGPKKTRSPEDWIPRPPERYTLTGHRSPITKVLFHPVYSVMVTSSEDATVKVWDYETGDFERTLKGHTDAVQDLAFDHTGKFLASSSADMTIKLWDFQGFECIRTLHGHDHNVSSISFLPSGDHLVSASRDKTIKMWEIATGYCVKTFQGHGEWVRRVRPNADGSLIASCSNDQTIRVWVVASRECKCDLRDHDHVIEDLNWAPESATPVINEAAGVEGGKKAMSPGPFLVSASRDKSIKIWDVSAGVCLVTLVGHDNWVRAVMFHPGGKFIVSCSDDKTLRIWDYKNKRCAKTLVAHEHFVTTLDFHKSAPFVATGSVDLTLKVWECR