uri

Gene

uri

Protein

Unconventional prefoldin RPB5 interactor-like protein

Organism

Drosophila melanogaster

Length

731 amino acids

Function

Inhibits the activity of serine/threonine-protein phosphatases flw/PP1beta9C and Pp1-87B. Required for germ line cell viability and differentiation, normal transcriptional activity and maintenance of DNA integrity.

Similarity

Belongs to the RNA polymerase II subunit 5-mediating protein family.

Mass

83.924 kDa

Sequence

MDRREDALLQALQTNASETERWEAFKRDNESTIRNLDKFAKNLSVEVMVPIGRKALMPGELIHTNELLVGHYEGYFSACSSHKAKEICQYRLKLAEEQLKKLAVENDLWQKKLHTPFAEGAVPSGDQVEIVEDFNEESHNKWLAEHRKRMRQQKQKERLEREAEPVKKDNEVLRKLEEREMMEELGLDPDNIDEDQLHDMLNQEPLKSTNESSPKSLTQEEEDELWKKLEAEEQNEADELSSEAEESLKTTDNLVRQLMSGETETPSSKKRTAGTNRNVEIQDPISEDDGDDDDEGDQEEEVRTIREQMSLLPNEDREPFLRAQLHVLKAKMRKIQKVNFISDELIHLMNVVVMLEDDLQDLVFEQELEASEEEEEVVENNHLPDEPSKELSTVSESSTNKRRISFALDDEKLEFRREETVAEMLPNAKKNSRDIIKLNAPLKPAGDPQPASIKTKRQTTQDILQKVERNIEFVKENQSVQDFDLLNRIMEESTGLINTLHISFTHSGAIPSPSSDQSDGIPGKPSDFYVRYEKDRARPNDSFPIYVNGFEGEEHVKVPIMSEAARGSAYEDPRSQFSKPNSSEICFTHSGSITPTSNDQSDDIPGNPFDFYEKYEKDRAKFSKSNSSEGDATDPESATKSILRNKSAVDLEPHNVNQQPKKGRKVRNQKKKERTLDDDLRDMSAYQKVMHDLVEKEPTAPEPLPPGKFIDSHAPKKRVSRFKEQRALNKT

Protein

Unconventional prefoldin RPB5 interactor-like protein: uri