unc-80

Protein unc-80

3263 amino acids

Probable component of the nca-1 sodium channel complex, a cation channel that regulates neuronal activity by transmitting depolarization signals to synapses. Regulates the transition from slow to rapid forms of locomotion. Required for localization of nca-1 along axons and in non-synaptic regions. Contributes to endocytosis defects in synaptojanin mutants. Involved in the control of anasthetic response to halothane.

Belongs to the unc-80 family.

366.998 kDa

MHVRYLQHEHTGTVQLLLMPLSTAASFKSAKWTEEEGEEECDSVPLPIQTFLWRQTNPFLGDKIGKLHEASCVTFERVVVQNILHGLSPSLSNALASVSRWKLVRAALPHVIQCCGSLLLANVGEKKLPTSLQKILYILHWMLIDSSSECIENASTKDDRSVCQSRTQGLFNISSIQLFIYLIAPLADVISEEEVVDNIRLESGLKVWQAIWQFRQPDVWCFSAPVKQRRDELPQITFARRQNPAQLDTQGIYLGKDENTVRRPSIVPPPKPPRTDVTVLNEKRKLEEEKMKMKEDYVAIEIEAPSLKPNDLLIDMSQGVRNKEFERTSSIVRSVSEYKTNLCGQKEKLATVSKSRTSDAFDSSPTSDSSANMLEEVEGIKFSENENCSLSAVFFSSDQAPLVNLSDICSGFSIEEPHDSTQSSVEVPQHPVLESSMFLSTTSSASDVPPFVLTRASTAEDTTSSCSQQTVIPLAMPVTTETTTLPVTLPKSALTKTTNENRRTDHQRMPSTQKSVSGSTDDELDEGSFSDPTIASYLDVAVIRALLITHWQEKGVYWALSYIHNRLIEIKAYMIIRKSTRQRSNSLPSGERKLSVAPEQLTNPVWDDLKIENKPEEGRSHLHVAFNDTERRKSSDNCLAPHPTTNSRRSSLNTLSRRGINRSNPSLSNSVEVLSIRDDAEDDVSNISSKSIEKENTKLNAVFYPEALGSTNFIEKDGKISATVIVQTVNQVMDRCTGVRQCELALNIADVLLGTPLEQTETFFVQLNIMVFKIYLCLGCPHGCNEGVKSPHGDFLRAKAKAILAGLERVQPDKFKNILNDYVDNYGTQQVIDLLHSITSFCRSELTALDGRRASESRVPSYRNTFNEKDKGIEGRIINATYKTLITKISVISAELSLPENMSLQQDVRLLVNFVQEHHGNPFRRVGLSALKDATCKNPTTSDFHTKEDQTGGSPGAQSQKQSNDQASLRRGLFKKKNEKSGGTTTGNDDSEGDSSPSTPRTVSSMDDGVSPLASTSYYKKKSAPKLHFAFGLLKSVKPDMDEEISDNENEEGTSNEEAGLPQRRPLRQSSKQVKARLPIDSKGGMRLWGTYVPPPNYIDAKGIFDGARRFAFLLETARPGTFPDAPLIAAIMHLKSPVLARASLLLECANLVSRCNRGQWPEWIRSSHHRTFSLGGALANRGTPSATRRMHSLQRQAGRYFYQWGVQIGEHISKLLELSENKSKKTLQMEDTIEDFFDDGIVNNQNGEKCPIALQFIAVLLLQEITAFLRETFKTIPRSKNSKPQTGNSGWDKLLSHRRWSILSNTFNAQQTGSVNSITEINSSIHLNDKERRISFSATEEDSPRGSKDAIDEINAVDKKGSIHMQVVRPPSLSARLFSRQSTHEESGGSAQGSTKSTTYVPETGRRIATGRQRLLKRGSPMATGTQPSLESSHKRKSFRNRKQSKQAHLEEEEKSDGGSLTSQQSPIVQRMRAASMRQSSNFLALFHHAIPEFLDAGATHILSARESLKPTDDGLQSPVESVHPVIIPHSNHGSAHSQQPVVLKSSMDDEEQHMLSNLPWIKVLIKFSNSFDLECNHVGVCSAKCFQRVHRQCFRMIESLSTLYGMERNVSTRADKRNLLADNWQAKQQALRKQTETNSARASIHARQSTAVPRRESAMVGQPEFASKAIKMMLMEKMQQEKEKEKEKEKEEKDALKKQSVEQDHSSTDTEEDAQLPEKNKPMLTYLRSLVLQLVHSPISSVLKCCLLLSVEQHKQMIEVCWKMLIHEDPHVVASAASMFIVASVKKSEESLLIIKTALDSQDPQVRTSGIQRFYTLWRNRFHAWLKMEDGAQASFKVPPPGIDFTLPSPAIGQSQLPVVDPPWMPHLKTKIEELSLKEEEHATSQTIMTMTRTRRKQKQEMVKRAVREAEERQSEQRQLFRLRSSAIVSLAAYEPALFHHQQEQTEESDNSHQHARHVMPVAQPLFPSALLSVVPQIIELLDDPQVDNNGVSVGDVAKKVIWTCIVEDPSLFLRHFLEKLTNRDRQVLISEYAPTPAYEALMSQLRKLVLRFHPLPSQAAHSLLNYLFGFVMHYVRAQCEGSEKAIGMALSICWLLSPNIHGLYFKDLKQTLKKEQCDQALMITANVPSAKKIIVHGLDSTSGGIPSQFPVHEDTQFHQILNDSLEFFNIDEDDLNCFYLTDTKTGVIHLPAAYVRDYYFFHRSFYPQLTLVKLSPEVAEKKMKETAFHQKFIECGKVLLTHNILKYSPQHVIAQRVFFLHDEFTHLPSFPRKSLETCFGMYFGPGGEQLKAMESMHKFVWAKMMSDMFEKMENAFMFADLHLFINVINGIMIMHCEDVLILRRCAATYISISIHFNTLFASQGFFLIMPTLLRCYSQRQTNKVFCGVVEFICRQFYTLHRKPFLLQMCGAIANIIDNSSNDFEINPMRVKAKYWFNLIKKMEEITDEDPLDILGLVPYEKPLKALDLCYRDDPNTFCALTDAMASCICVCAFSPESKRSHHMLLIMQAMLPHMMKRLEEETLQSGNSPAAVKHEISQWITMAVEMKALINSCEQLVRGPTRAFDLVNSVSERGKSFVADSPQFFDPPTTNEDENSRPYHLKEKRSTAVAWEAAEVEEQQKETYRRPRDTLLQLIAAYIEMASVRLKELTKLGANLEHAKIPDVLDHKCYVKLGEVALALLKVAPYDLSTTTCHGLQKYFQIILPVTDWSIESNRSALNIILRRLDKTLSKIAKRQSFRKRAIWIALSSWINGICDTLNAFPYIAHLHPLRTITQLCLRMMVGDPCVEDSAASTALHPTTVLHPTPPPQTFANAVLRLTTILMQALGQFAFSLDFVTSTEGMGVSSERLEAVLCHVLIPLFLRIPNNPKEQSIFQAKDLSQCLTVMQNAISPPLVKQQAPPLISTSTLTTTFIRGAQDVTGRQGSVSVTDRGHSATVSTHRIVRESICQAIYLGLKVLMLTFGKLLAPMWPRVARIVKDLLAKKPGAPTSMAFVDFLLHSNLPISLFILPMIQNKMKQKPGTDQEAAWQTEILEKLDAKSHNIVPPSILLVKCYQELQQLKEELTMKPIEMTRSYTPTMADPHSDSSAASTAPRGASSRQSIDRRTSVHMKKVLPTMKEDIPEDPEDSEDVIDSNSTGQVTSRISKSPSIPLNKTHQSSRTRSVSGFGMWRSVRRKSRHVSSAEESSEERGSVELHDVGHHSALHEPNRTPNRRSTEALVLPLHESIDTNRHRFVSFSTPKKTHEVSEDVFQITEQHQLV