Protein
Uridine 5'-monophosphate synthase
Organism
Caenorhabditis elegans
Function
Bifunctional enzyme which catalyzes the formation of UMP from orotate in the de novo pathway of pyrimidine biosynthesis (PubMed:19645718). May also form UMP from uracil (PubMed:19645718). Regulates the size of gut granules during embryonic development (PubMed:20148972). Involved in resistance to DNA damaging agents including UV-C and X-ray radiation (PubMed:24262006).
Similarity
In the C-terminal section; belongs to the OMP decarboxylase family.
Sequence
MSSLTDKTRNGALKRNLLRQMLKASVFKFGEFQLKSGQISPIYIDLRECFGHPGLLMLISEAISKQVEISEVQYAGVLGIPYAALPYASVAAGNYLKKPLLIVRKEAKSYGTKKLIEGLYQPNDRLILIEDVVTTGGSILDVVKVLHTENLVASDVFCILDREQGGRQKLQDAGVTLHSLLDMQTVLTFLYSTGAIGDEQWHGIVQALNLPYTSPTKLEINSELENLSSLPYVENVRTPLAERESLTESALIKKILGIMRRKKSNLCLAVDYTTVEQCLQMIELAGPFVLAIKLHADAITDFNEEFTRKLTTMANDMDFIIFEDRKFGDTGNTNLLQLTGAQKIANWADVVTVHAVQGSDSIAGVFRKLAKDPTYRLSGVLLIAQLSTKGSLTALEGYTETAVKIANENRDVISGFITQTRVSACSDLLNWTPGVNLDAKSDSAGQQWRGVDEAIEVQQNDIIIVGRGVTSSSEPVQQLKRYRQIAWDALTRSDDSI