Function
Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own (PubMed:15530417). The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63 (PubMed:15530417, PubMed:24595290). Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies (PubMed:24595290). Required for glr-1-containing glutamate receptor trafficking in neurons (PubMed:21179194). May have a role in synaptic transmission at motorneurons (PubMed:21179194). May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates (PubMed:17663792, PubMed:22494772).