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ube2s-c

Gene
ube2s-c
Protein
Ubiquitin-conjugating enzyme E2 S-C
Organism
Xenopus laevis
Length
211 amino acids
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Similarity
Belongs to the ubiquitin-conjugating enzyme family.
Mass
23.338 kDa
Sequence
MNSNVENLPPHIIRRVYKEVSTLTSDPPEGIKIIPNEEDITDVQVHIEGPEGTPYAAGIFRMKLILGKDFPAAPPKGYFLTKIFHPNVSNNGEICVNVLKKDWKAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYASRAKLMTEIHAQGSTLRGKDPTDPCSSASATVVSGDGPMAKKHAGDRDKKLAAKKKTDKKRALRRL