uba2-a

SUMO-activating enzyme subunit 2-A

641 amino acids

The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

Belongs to the ubiquitin-activating E1 family.

70.805 kDa

MAVIGALPKEVAEAVSASRLLVVGAGGIGCELLKNLVLTGFTNLDVIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFCPDANITAYHDSIMNPDYNVEFFKQFTMAMNALDNNAARNHVNRMCLAAGIPLIESGTAGYLGQVSVIKKGVTECYECQPKPTQKTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVAPDIADPEAAWDPTKAAERANASNVDGDIKRVSTKQWAKSTGYDPIKLFNKLFRDDIKYLLTMDRLWRKRKPPIPLEWASLHNKENCSEIQNESSLLGLKDQKVLNVASYAQLFSKSVETLREQLREKGDGAELVWDKDDVPAMDFVTAAANLRMHIFSMNMKSKFDVKSMAGNIIPAIATTNAVISGLIVLEGLKILSGNTEQCRTVFLNKQPNPRKKLLVPCSLDPPNPSCYVCAIKPEVTVKLNVHKVTVQMLQDKILKEKFAMVAPDVQIEDGKGTILISSEAGETDANNHRKISEFGIRNSSQLQADDFLQDYTLMMNILHSDEMEKDVDFEVVGDVPEKGPQKPPEESVKNITNGSDDGAQPSTSKAQDQDDVLIVDSDEESPSSSNADVGMESASLKRKLPDEEAVSSTKRKRIEPPVEEDDDIIALD