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uap56

Gene
uap56
Protein
ATP-dependent RNA helicase uap56
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
434 amino acids
Function
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity. Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC).
Similarity
Belongs to the DEAD box helicase family. DECD subfamily.
Mass
49.231 kDa
Sequence
MASAQEDLIDYEEEEELVQDQPAQEITPAADTAENGEKSDKKGSYVGIHSTGFRDFLLKPELLRAITDSGFEHPSEVQQVCIPQSILGTDVLCQAKSGMGKTAVFVLSTLQQIEPVDGEVSVLVLCHTRELAFQIKNEYARFSKYLPDVRTAVFYGGINIKQDMEAFKDKSKSPHIVVATPGRLNALVREKILKVNSVKHFVLDECDKLLESVDMRRDIQEVFRATPPQKQVMMFSATLSNEIRPICKKFMQNPLEIYVDDETKLTLHGLQQHYVKLEEKAKNRKINDLLDSLEFNQVVIFVKSVSRANELDRLLRECNFPSICIHGGLPQEERIKRYKAFKDFDKRICVATDVFGRGIDIERVNIVINYDMPDSPDSYLHRVGRAGRFGTKGLAITFSSSEEDSQILDKIQERFEVNITELPDEIDVGSYMNA