Protein
O-mycaminosyltylonolide 6-deoxyallosyltransferase
Organism
Streptomyces fradiae
Function
Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. Catalyzes the transfer of 6-deoxy-alpha-D-allose from dTDP-6-deoxy-alpha-D-allose to O-mycaminosyltylonolide (OMT) to yield demethyllactenocin.
Similarity
Belongs to the glycosyltransferase 28 family.
Sequence
MRIALLTMGSRGDVQPFVALGTGLRARGHEVVLGAPEALRPLVEQAGLEYRATPGDPDGFFTMPEVVETLRRGPAMRDLMKALPPAPEEYDQEVLDRIERAGEGVDLVVHAPLTVTTALGEPSTPWLSVNWWPNTSTWTFPAVESGQRRMGPLTPLYNRLTHWRAEREDWGWRRAEVNEFRGRRGLPPFGKSSPLRRLGHPRPHLYPFSPSVLPKPRDWPGQCHVTGYWFWDQPGWRPSPELEDFLADGEPPVLLTLGSTWPVHRQEEMVEYAVAAARGARRRLLLVGGPEGALPGDALRVPSADYSWLMPRTAAVVHHGGFGTTADAVRAGVPQVLVPVFADHPFWAARLRRMGTAARPVPLARMNREALAASVRTAVTDPAMAVRARRLGEAVAAERGVENACVLIEEWAETRTTAHTPG