Protein
Tylactone mycaminosyltransferase
Organism
Streptomyces fradiae
Function
Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. Catalyzes the transfer of alpha-D-mycaminosyl from dTDP-alpha-D-mycaminose to the 5-hydroxyl group of tylactone to yield 5-O-mycaminosytylactone. It can also accept 16-membered tylactone and 12-membered ring macrolide.
Similarity
Belongs to the glycosyltransferase 28 family.
Sequence
MRRALDDRRRGPHGPEGKPPMRVLLTCIAHNTHYYNLVPVAWALRAAGHEVRVAAQPALTDTITASGLTAVPVGGNESVLEFVTEIGGDPGPYQRGMDFAETCGEPLSYEHALGQQTAMSALCFAPFNCDSTIDDMVALARSWRPDLVLWEPFTYAGPIAAHACGAAHARLLWGPDVILNARAQFRRLAAGQPEERREDPVAEWLGWTLERHGLTAERETVEELIGGQWTLDPTAESLRLPAAGRVVPFRFVPYNGRSVLPDWLLRKPGRPRVCFTLGVSARETYGRDAVPFHELLAGLGDLDAEIVATLDPGQLSGAGEVPRNVRAVDFVPMDALLPTCSAVVHHGGAGTCFTATLNGLPQIVVAALWDAPLKGAQLAEAGAGVSIAPEKLDAATLRAGVVRALEDEDMRRSAGLLRAEMLAEPTPAGLVPQLERLTALHRNGRSRSAPER