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tylMII

Gene
tylMII
Protein
Tylactone mycaminosyltransferase
Organism
Streptomyces fradiae
Length
452 amino acids
Function
Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. Catalyzes the transfer of alpha-D-mycaminosyl from dTDP-alpha-D-mycaminose to the 5-hydroxyl group of tylactone to yield 5-O-mycaminosytylactone. It can also accept 16-membered tylactone and 12-membered ring macrolide.
Similarity
Belongs to the glycosyltransferase 28 family.
Mass
48.66 kDa
Sequence
MRRALDDRRRGPHGPEGKPPMRVLLTCIAHNTHYYNLVPVAWALRAAGHEVRVAAQPALTDTITASGLTAVPVGGNESVLEFVTEIGGDPGPYQRGMDFAETCGEPLSYEHALGQQTAMSALCFAPFNCDSTIDDMVALARSWRPDLVLWEPFTYAGPIAAHACGAAHARLLWGPDVILNARAQFRRLAAGQPEERREDPVAEWLGWTLERHGLTAERETVEELIGGQWTLDPTAESLRLPAAGRVVPFRFVPYNGRSVLPDWLLRKPGRPRVCFTLGVSARETYGRDAVPFHELLAGLGDLDAEIVATLDPGQLSGAGEVPRNVRAVDFVPMDALLPTCSAVVHHGGAGTCFTATLNGLPQIVVAALWDAPLKGAQLAEAGAGVSIAPEKLDAATLRAGVVRALEDEDMRRSAGLLRAEMLAEPTPAGLVPQLERLTALHRNGRSRSAPER