Protein
Macrocin O-methyltransferase
Organism
Streptomyces fradiae
Function
O-methyltransferase that catalyzes the conversion of macrocin to tylosin, the ultimate step of tylosin antibiotic biosynthesis. Also able to mediate the conversion of lactenocin to desmycosin.
Similarity
Belongs to the methyltransferase TylF/MycF family.
Sequence
MAPSPDHARDLYIELLKKVVSNVIYEDPTHVAGMITDASFDRTSRESGEDYPTVAHTMIGLKRLDNLHRCLADVVEDGVPGDFIETGVWRGGACIFARGLLNAYGQADRTVWVADSFQGFPELTGSDHPLDVEIDLHQYNEAVDLPTSEETVRENFARYGLLDDNVRFLAGWFKDTMPAAPVKQLAVMRLDGDSYGATMDVLDSLYERLSPGGYVIVDDYCIPACREAVHDFRDRLGIRDTIHRIDRQGAYWRHSG