Protein
Demethylmacrocin O-methyltransferase
Organism
Streptomyces fradiae
Function
O-methyltransferase that catalyzes the conversion of demethylmacrocin to macrocin, the penultimate step of tylosin antibiotic biosynthesis. Also able to mediate the conversion of demethyllactenocin to lactenocin.
Sequence
MAVQKEATLVRQIIRAAGGHAADVRELVAEHGPEAVTAVLVDEIVSRAPHPVNDVPVLVELAVRSGDALVPRRLAVAQGAPVRRAAPDDDGFVAMRVEYELDELVRELFGPCRERAAGTRGTTLFPYATSGTGHIDTYFLAAQQATATVLAGCTSAKPDLNELTSRYLTPKWGSLHWFTPHYDRHFREYRNEEVRVLEIGIGGYQHPEWGGGSLRMWKHFFHRGLIYGLDIEDKSHAEEQRITTVVGDQNDPGCLTELAARYGPFDIVIDDGSHINEHVRTSFHALFPHVRPGGLYVIEDLWTAYWPGFGGDSDPGKSDLTSLGLVKSLVDSLQHQELPEDSGRSPGYADRHVVGLHVYHNLAFIEKGVNSEGGIPGWIPRDFDALVAASSGGAA