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tut-1

Gene
tut-1
Protein
Cytoplasmic tRNA 2-thiolation protein 1
Organism
Caenorhabditis elegans
Length
373 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Similarity
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
Mass
41.332 kDa
Sequence
MEKRRGPPPCQSGSGCSNPAKIRKAKDGAQLCGPCFSRNFEDDVHEAIVNNKLFKRGERVAIGASGGKDSTVLAYVMKTLNDRHDYGLDLQLLSIDEGIKGYRDDSLLAVEKNRVEYGLPLTILSYRDLYGWTMDDIVAKIGKKNNCTFCGVFRRQALDRGAFKIGATKLVTGHNADDMAETLLMNVLRGDIARLERCTNIVTGEEGDLPRAKPLKYCFERDIVMYARTNQLEYFYTECIYAPNAYRGYARKYVRDLEKVHPRAILDLIRSGEKVSVKKEVEMPTLKICERCGYMTSQKLCKACLLIEGLNTGNTDLGVRKSKKSKKVTVEADELNKEGGCGSGGGGGGCGCAGAEDAAENEETRQRLKDLQF

Gene
tut-1
Protein
Cytoplasmic tRNA 2-thiolation protein 1
Organism
Caenorhabditis briggsae
Length
372 amino acids
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Similarity
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
Mass
41.317 kDa
Sequence
MEKRRGPPPCQSEEGCSNSAKIRKAKNGAQLCGPCFSKSFEDDVHETIINNNLFKRGERVAIGASGGKDSTVLAFVMKTLNDRHDYGLDLQLLSIDEGIKGYRDDSLLAVEKNRVEYGLPLTILSYNDLYGWTMDDIVAKIGKKNNCTFCGVFRRQALDRGAFKIGATKLVTGHNADDMAETVLMNVLRGDIARLERCTNIVTGEEGDLPRAKPLKYCFERDIVMYARSNQLEYFYTECIYAPNAYRGYARKYVRDLEKVHPRAILDLIRSGEKVSVKKEVEMPTLKTCERCGYMTSQKMCKACLLIEGLNTGNTDLGVRKSKKTKKVIVETEGGKKEDGGCGSGGGGCGCAGAADETENEETRKRLKDLQF