Protein
Modification methylase TthHB8I
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Function
This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the TthHB8I endonuclease.
Similarity
Belongs to the N(4)/N(6)-methyltransferase family.
Sequence
MLFPPSLPPTASGRSLGRVETPPGLVRFMVGLAEAPKGGRVLEPACADGPFLRAFREAHGTGYRFVGVEIDPHALDLPPWAEGVVADFLLWEPGEAFDLILGNPPYGIVGEASKYPIHVLREVKGLYKKTLSTWKGKYNLYGAFIEKSVRLLREGGTLVFVVPATWLVLDDFSLLRSFLAREGRTEVYYLGEVFPGRKVSAVVLRFRKGGKGLALWDTRRDGETFTPLLWSEKPEWKGEIIRFETGWTREMEASGPPLGSLFHIRFAARSPEFKKHPAVQKEPEPGLVPVLTGRNLKPGWIDYESNHSGLWMPKERAKELRDFYATPHLVVAHTKGTKVVAAWDEKAYPWREEFHLLPKEGVELDPLFLVEWLNSDKIQEYVKTLYRDFVPHLTLRMLERIPALLPRKGNTERRKHGPYTSPESAGSF