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tsg

Gene
tsg
Protein
Protein twisted gastrulation
Organism
Drosophila melanogaster
Length
249 amino acids
Function
Involved in dorsal-ventral patterning. Required for specification of a narrow strip of dorsal midline cells that will give rise to the amnioserosa, but not for specification of dorsal ectoderm cells. Inhibits BMP signaling; enhances the binding of sog to dpp, thus enhancing the antagonistic activity of sog.
Similarity
Belongs to the twisted gastrulation protein family.
Mass
27.22 kDa
Sequence
MQLLCYFVILFVGIAPWSSLANDDGCNEVVCGSVVSKCLITQSCQCKLNDCHCCKDCLNCLGELYIECCGCLDMCPKHKDVLPSLTPRSEIGDIEGVPELFDTLTAEDDEGWSTIRFSMRAGFKQRVQGGASGDAGNGNGNGNAGSAGVTLCTVIYVNSCIRANKCRQQCESMGASSYRWFHDGCCECVGENCLNYGINESRCRGCPEDQDQLLTADTVPAEAEQDLERFFGNEEIEDEWGYGEEDEFS