trr-1

Transcription-associated protein 1

4115 amino acids

Influences germ cell fate in hermaphrodites (PubMed:24098152). Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions (PubMed:24098152). Required for spermatogenesis and embryonic development (PubMed:24098152). Acts with tra-2 to promote expression of fog-3 and control male tail development (PubMed:24098152). Involved in the negative regulation of vulval development (By similarity).

Belongs to the PI3/PI4-kinase family. TRA1 subfamily.

475.19 kDa

MDPSIPSTSHRSVPPDRGVQPDRNLHVQELENRIQSLVHGGQRDDVKLKELQDIWASLENHFTASSHEKVVEKLVLSILQLFCNTSPQFISENNTQMLRKLMLEILLRLSNTDPVKTHSKEILKQMMRLIGVENEENAILAIRILIDQGRYGKLDYCREVQSLLLLMRTMVKELAESGRTAEMFLVRELTVPPATSSEEQLIAEYLTKCYYAQPVILNAKDGLQGPKFNMIPSAHQSIKVLLEMPFLVIFFYQNFKTTVQTEALEFTRLCLDFLNVPVPADKTKYHDVLTDDFVTVQSKILSFVNIMAKIPAFMELLQQNGDSLVSGTMQMLERCPPDLISVRREVLLAVKYFTAGEMKSRFFTMLPRLISEHFILGTGFTAIELLRVFMYQMLADLMHHTRDTISYELISHVVFVFCRALHDPNNSAQVLIMSARLLNSLAESLCRMESQAPIRDLMLEILEAQVSKLKVMAVYHIPILFQQYGTEIEYEYRNYERESEKPKVNVMKESTQREVPKRRTRKLSMDSVEELEFLVTDNVNMTESEQKRNELPTPTKEHTKKTSPEAILNSLYAASTQPLGLSETRNLIKYVMHTCKYVTGQLKISRPSTEMYHCVRERDLYERLLRYGIMCMDIYVLPAVKNQAQAHASQRTKEEKEALESLANVFTSIDHAIFRELFEKYMDFLIERIYNRNYPLQLMVNTFLVRNEVPFFASTMLSFLMSRMKMLEVSSDKTALYVKLFKIIFSAIGANNSTIYQDRMLTNYLPEILKQSTVLALTAREPTNYFLLLRSLFRSIGGGAQDMLYGTFLQLLPNLLQFLNKLTSCQHRIQMREIFVELCLTVPVRLSSLLPYLPLLMDPLVCAMNGSPNLVTQGLRTLELCVDNLQPEYLLENMLPVRGALMQGLYRVISKAPDTASMKVAFRILGKFGGANRKLLNQPQLLQVRRFPDSYLNMEFSQMGLDGNHSLHLPISELMRVAADQMRYPADQIFNPNPTNIPSPHVKKCCMELSKAVLLAGLGSSGSHTVPTKDLPKVLKKLLTGFNVNQRTTEIYICPKENDREVYVNALLVVAYGIWNKDGLRQLYSRFFVKIIRQFALMGAIEFVSGNGWMQNADEEGALPLCLDSSVLVDALITCLSETSTSFFYGGIMCLRYINETLELALPDINQMSKVPLCKYLMEKVLKLCHGPAQYARAGGINAFMYMIEHYPRKFIMDFVIDVVDAIMEVLLGLVEEISSGSADIATDCFKKMMRTYFIQEENQEEENLTLASIFVAVFGKHYFHGNDRIRDYMAQLMEYCMIQSRLETNLDKFYYRFREFFEPELIRIMETLPTMSLTDAQGSLDGLQRFVFICPEGFEFEKDSEIYKRYLVHLLDLAQTDTQTINQRNAFKKCETCPSHFLPPFPILHHIDQMRGSALQCLVIAYDRLRKQLENTTRDIEDEQLMSEILAMNSPRITVEQIFENNESWRRLMTVLLRAITDKDIPDIADKLYPALMRVTPVPTNIIATFGANYIRNISRANDENDPDRTITYHDCRKFSILVELNPKILVRNIVKNLANHIIKYNMSDSISNILVMPNEAKEEEVEAYEAEKKRGVRDLEMIGYTAKMLAGCSMEILTAEIIIDITRFAAKFEYTYSQDVLPNWIDDVVKLMNKAPVEVWKFFLLRESVANPARRSLIRRAIIFPTSEPLRKVFMQTPEYLERLIDSNLDNYDNSDERVIIDREMFLLSLVDRISRNCHDWLSDPSLSPIPQLRAFFNGTEFMDRYSVRSIMVEEAREIRVISMTEDKYKVPKLMTNIFLRYLRFVRKYFPVKLIFYRNNIQDYDMFFNVVSVFMGKFQTDFTFVREYLEVEVIPKMPLWWRREIFIKVMVMFEENAQKACKDFRILKALQYLILPSLQWAFERYDTDEIVGSAPIDDSENAADAESSNNTENLVGRLTSVIGAHRLDFSDGMIILFYQLCTLFVQHAPEHIHNNHCKKQGGRLRNFMLFAWPCLATPNRQDPTLRYTGFFFLANIIERFTINRKIVLQVFQQLMTNYQQDTRDQVRRAIDILTPALKVRMEDGHQQILTQVKKLLIEEGHILQHIQHILGTIIRNWRVYYHIRHEILTPLLNAVQRALTMPNSVIEHAQTRKQAIEVCEMIIKWELLKLHKTDHIITDDEANEVDKLYEKLRGASSPDRYDFEDQQMKKDLLDSQRVITREHVDIVVNMLMRFCVMFHTSAQNNSTSGQQGAELVKKCQLLLRICLRSSVWGDFVNIRTSILNNYIVVPSELIPKQNEVQNPEYVLAANNSQYTIEMLNVIVPILPKPTLKNVLNILQPALIGVIQSSGHMSRGITQLISRLGERTSVSTNGLDEFELLNSYIVKYIHDSFSTILRCVLIWISIYSLNPFFRNQNAPVLSVLGSFTLLRAMCGHEAGFLDNFMPTFLKVMDRVAREHLQFNSRQQPSVQKNLSELTCVCMELVRQRIDHIGLELKRTTITDVMTELIFKSTSERVIQVCAKLIGAMLSPTDMEFSLHTCLQQLVRIQSVIISKFKNCKEVITEFLVVVIKVFENAEYRNSEYGARLWEAFFWGLKSTDPTTRDSFSAVWEMTWPQMSTADICHRMKYIMKHQDWSKFKHAFWLKFALWGMLRAISKRPKSVNNPKKKVVMLNCATPWRTIEYAARLKEQHMETDPMIKLEEPEPMEVDQPKNAPAEEPKDNKLSLDDFLAGQQELLEEAAEFDFADALDTVSQITFGINDNGMTSRIWVTFFKSFWASLQPREVEDFTALIVPFLSSGVHNQFQTGVQDSVLAVWLEAIGEKVPLPSSLIEFISSKHECWYTGISILESSIWSIPKQLNNTLLGNINCDRSLTSNIETLESLGALYKELAEFDQYSAIWERRSVFPETMKAMSALQLGDMDTAASILEQAMNKEMEHLPVPTANAAPPGPNDRQISPIYDREYEQWMQMYMSSCSELLQWQTVAEISNSREVQDVRGIITAASHIPDWNLVEDCRSMLSGCIPPDFHLEYTVFNLMSTVMRLNESVNVPHARERCKQALQECIEAHISRFRALPSVTSYGHVKILQSMNLVRDIEESMEVRIALLEQPTKMDQSLMMDMKSLMKVYRNRTPTTADDMGFVATWYDWRNQIHGMMLQRFEWFDKSSLSTTGNGNQSIVPIHSMAQAQLTVAKHAKSLGFNNLAKDLLNKLGGLPAIPMMDAVDKVCTYGKTLRALSNNVDDERSKQELLYEALEVLEDVRIDDLQKDQITSLLFNRATIHSALGQTANADRAFSAAVQLTDMKTANVPTGIKLFRQWGNHLNKLFFDQSQMVSKETSENFGRQALSCYFVAARVDGDLKARKPIAKILWIAKHLMASGASEALNRVIQKHLPSLNLFNWLYWIPQLVTEISHQPNNNFIMVLCRVSLKSESFNSNGASKVSKSGISGPRKQSKVTPRFPRFLIEQNLNQCDDIAAAHPLQVFYHIREAVSVEDIDAVFAQDYTEEEMSMDTPDDEAFSNDPPFSRALKICLKYRPTDIRVLHRILKELDQMTETWVERHLRFAVAIKDQLFEDFAEQMDARFNEMQFSGAVYELTQKWKRQLEEDYKFFENNYNLDLLEIRNRRRVIVTKGYMGTVPSQIMFEKELSQVFTDPPEMKDEFEYVTEITKVIFDQLDIRSPQAPRPALFVRTVMEWIRIIRRRFDRLPRRVPMEISSPYLARFSHRTGCIEMPYDLLNVLRAKNHSLNATNQTGQYISMMSRFEPYFEIVMRGGQVTRKIYLRGQTGKSAAFYLKKSIKDERTNRVPQMFKHVDYLLQNDRETARRHLSVPSLLQMRVSKNTTFCEIASVQPYAIPQDCSRNYPASQIEVMHPYEVLTSTFNGLYSPDDMVMHFYERFADSCSSIGQPLPQNIDPSMASQPRLTEPHHVKNIIYEDFARDMIPFRLLTDYLLARYPDPVMFYAMRKQFIHSFAVLSIIEYHCNLSPMTPHQMIISMNTGVLNNPFYRFELGTGQLMDIEHFAHEVPFRLTPNLMMFVGVAQDGDLLWSMAAVARCLMKKEPGAVMRPLLWDEYANNVNYENMIYICHAANSYVKCIENKVAMTNRHDAKVKKDDCNSLIIRAKDSDNLSRMPPTYHAWF

trr-1

Transcription-associated protein 1

4064 amino acids

Influences germ cell fate in hermaphrodites (PubMed:24098152). Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions (By similarity). Required for spermatogenesis and embryonic development (By similarity). Acts with tra-2 to promote expression of fog-3 and control male tail development (By similarity). Involved in the negative regulation of vulval development (PubMed:15068795).

Belongs to the PI3/PI4-kinase family. TRA1 subfamily.

466.866 kDa

MDPAMASPGYRSVQSDRSNHLTELETRIQNLADNSQRDDVKLKMLQEIWSTIENHFTLSSHEKVVERLILSFLQVFCNTSPQFIAENNTQQLRKLMLEIILRLSNVEAMKHHSKEIIKQMMRLITVENEENANLAIKIVTDQGRSTGKMQYCGEVSQIMVSFKTMVIDLTASGRAGDMFNIKEHKAPPSTSSDEQVITEYLKTCYYQQTVLLNGTEGKPPLKYNMIPSAHQSTKVLLEVPYLVIFFYQHFKTAIQTEALDFMRLGLDFLNVRVPDEDKLKTNQIITDDFVSAQSRFLSFVNIMAKIPAFMDLIMQNGPLLVSGTMQMLERCPADLISVRREVLMALKYFTSGEMKSKFFPMLPRLIAEEVVLGTGFTAIEHLRVFMYQMLADLLHHMRNSIDYEMITHVIFVFCRTLHDPNNSSQVQIMSARLLNSLAESLCKMDSHDTFQTRDLLIEILESHVAKLKTLAVYHMPILFQQYGTEIDYEYKSYERDAEKPGMNIPKDTIRGVPKRRIRRLSIDSVEELEFLASEPSTSEDADESGGDPNKLPPPTKEGKKTSPEAILTAMSTMTPPPLAIVEARNLVKYIMHTCKFVTGQLRIARPSQDMYHCSKERDLFERLLRYGVMCMDVFVLPTTRNQPQMHSSMRTKDEKDALESLANVFTTIDHAIFREIFEKYMDFLIERIYNRNYPLQLMVNTFLVRNEVPFFASTMLSFLMSRMKLLEVSNDKTMLYVKLFKIIFSAIGANGSGLHGDKMLTSYLPEILKQSTVLALTAREPLNYFLLLRALFRSIGGGAQDILYGKFLQLLPNLLQFLNKLTNLQSCQHRIQMRELFVELCLTVPVRLSSLLPYLPLLMDPLVCAMNGSPNIVTQGLRTLELCVDNLQPEYLLENMLPVRGALMQGLWRVVSKAPDTSSMTAAFRILGKFGGANRKLLNQPQILQVATLGDTVQSYINMEFSRMGLDGNHSIHLPLSELMRVVADQMRYPADMILNPSPAMIPSTHMKKWCMELSKAVLLAGLGSSGSPITPSANLPKIIKKLLEDFDPNNRTTEVYTCPRESDRELFVNALLAMAYGIWNKDGFRHVYSKFFIKVLRQFALIGVLEYIGGNGWMRHAEEEGVLPLCLDSSVMVDALIICLSETSSSFIIAGVMSLRHINETLSLTLPDIDQMSKVPMCKYLMEKVFKLCHGPAWYARSGGINAIGYMIESFPRKFVMDFVIDVVDSIMEVILGTVEEISSGSADSAYDCLKKMMRVYFIKEEGQEEENLTLATIFVSAISKHYFHSNERVREFAIGLMDHCMVHSRLAPSLDKFYYRFKEFFEPELMRVLTTVPTMSLADAGGSLDGVQNYMFNCPDGFDFEKDMDMYKRYLSHLLDIAQTDTFTLNQRNAFKKCETCPSHFLPPFPITTHIDSMRASALQCLVIAYDRMKKQYIDKGIELGDEHKMIEILALRSSKITVDQVYESDESWRRLMTVLLRAVTDRETPEIAEKLHPSLLKVSPISTIIIATFGASYIRNISGAGDDSDSDRHISYNDIMKFKCLVELNPKILVTKMAVNLANQMVKYKMSDKISRILSVPSSFTEEELDDFEAEKMKGIRELDMIGHTVKMLAGCPVTTFTEQIIVDISRFAAHFEYAYSQDVLVNWIDDVTVILNKSPKDVWKFFLSRESILDPARRSFIRRIIVYQSSGPLRQEFMDTPEYFEKLIDLDDEENKDEDERKIWDRDMFAFSIVDRISKSCPEWLISPNSPIPRIKKLFSETEFNERYVVRALTEVKKFQEEIIVKRMTEHKYKVPKLILNTFLRYLRLNIYDYDLFIVIASCFNGNFVTDLSFLREYLETEVIPKVPLQWRRELFLRIMQKFDTDPQTAGTSMQHVKALQYLVIPTLHWAFERYDTDEIVGTAPIDDSDSSMDVDPAGSSDNLVARLTSVIDSHRNYLSDGMVIVFYQLCTLFVQNASEHIHNNNCKKQGGRLRILMLFAWPCLTMYNHQDPTMRYTGFFFLANIIERFTINRKIVLQVFHQLMTTYQQDTRDQIRKAIDILTPALRTRMEDGHLQILSHVKKILIEECHNLQHVQHVFQMVVRNYRVYYHVRLELLTPLLNGVQRALVMPNSVLEKFSWQTRRHAVEICEMVIKWELFRTLKTDHIISDEEALEVDKQLDKLRTASSTDRFDFEEAHNKRDMPDAQRTIIKEHADVIVNMLVRFCMTFHQNSGSSSTSQSGNHGVELTKKCQLLLRAALRPSMWGEFVSFRLTMIEKFLSIPNDNALRNDISSTAYANTIQNAQHTLDMLCNIIPVMPKTSLMTMMRQLQRPLIQCLNNGAQNFKMTRLVTQIVSRLLEKTNVSVNGLDELEQLNQYISRFLHEHFGSLLNCRNLSGPVLGVLGAFSLLRTICGHEPAYLDHLMPSFVKVMERAAKEHLAYVANSQDGNMVKNFFPDVAELLCACMELVRPRVDHISMEIKRSIVGGIIAELIIKSNHDKIIQTSVKLLGAMISTQDMEFTILTVLPLLVRIQSIIVTKFKNCKDLIADYLVVVITVFENSEYRNSEAGSRLWEGFFWGLKSSDPQTREKFSIVWEKTWPHMATVDIAHRMKYIMQNQDWSKFKHAFWLKFALWGMLRTIAKRPTDPNNKRKKVILLNCATPWRTIEYAAKLKDQPMEVETEMKREEPEPMEVDEKDSQDDSKDAGEPKEKEKLTLELLLAGQQELLDEASNYDFADALDTVSQITFALNENQVTSKMWVVLFKSFWSSLSQSEIEDFTALVVPFMSSGVHNNYQTGVQDSVLAVWLEAVGDAVHLPSRLIEFISSKHECWHTGIRLLENHIWTIPKQLNNTLLREMKVAPGLAGDIETLESLGTLYNEISEFDQFAAIWERRAVFPDTMRAMSAMQLGDMELAQSYLEKSMSSTYETLAPTINPNNTSNSEKHVSPIIDKEYDHWMEMYITNCSELLQWQNVADVCNGKDMQHVRGLINAASHIPDWNVVEECKSQIAGCIPPSFHLDYTLFNLMSTVMRMNENSSPTHMKERCKIAIQECTEAHISRWRALPSVVSYGHVKILQAMNLVREIEESTDIRIALLEAPSNKVDQALMGDMKSLMKVFRNRTPTTSDDMGFVSTWYDWRNQIHGMMLQRFEYWDKVGLNVAATGNQSIVPIHSMAQAQLAVAKHAKNLGFHNLTKDLLNKLAGLTAIPMMDAQDKVCTYGKTLRDMANSAADERVKNELLCEALEVLEDVRIDDLQKDQVAALLYHRANIHSVLDQAENADYTFSAASQLVDLQNSVTTTGIKLMKNWGHHLYKRFFSTTVCKETGNNFGRQALACYFIAARVDNDIKARKPIAKILWLSKHLNACGSHEVMNRVIKKQLHSLNLFNWLYWLPQLVTDVRYKPNSNFVLILCKMAAAHPLQVFYHIREAVSVDDIDSVLEEDYTDEQMSMDVSDEDCFADDPPFDRILKICLKYRPTDIRVFHRVLKELDEMNETWVERHLRHAICLKDQMFKDFSEQMDATFNEMQYSEDVTMMTLRWRKQLEEDLVYFQQNYNLDFLEIRNKRKMIVTKGCMGVEKSQIMFEKELSQVFTEPAGMQDEFDFVTNMTNMMVSQLDIHAVDAPRPQGYIRIVLDWIRAIRRRFDRLPRRIPLESSSPYLARFSHRTGCIEMPYDLLNVLRAKNHTLMASNQTGQYISMLSRFEPNFEIVIKGGQVIRKIYIRGQTGKSAAFYLKKSVQDEPTNRVPQMFKHLDHVLQTDRESARRHLHAPTVLQMRVGQKTTLYEVASVQPYAMPPDCTRNYPASQIDIVHPYDVLTATFNGSYYPDDMVLHFFERFAQSSSSIGQPLPTPTNQDGTVAPPRLTEAHHIKNIIYEDFARDMIPFRLLYDYLTARYPDPVMYYAMKKQLLHSLAVLSTIEYHCNLTPMGPDQMMMTMNTGVLSNPSYRFEIRGGRSLHDIQHFGHEVPFRLTPNLSILVGVAQDGDLLWSMAAASKCLMKKEPEVIMRPLVWDEFANNTDCDKSRLQVFACHASNSYINGVASKLRNTNSADAKLRKDDCVSLISRAKDSDNLARMPPTYHAWF