TRMT5

tRNA (guanine(37)-N1)-methyltransferase

509 amino acids

Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

58.246 kDa

MVLWILWRPFGFSGRFLKLESHSITESKSLIPVAWTSLTQMLLEAPGIFLLGQRKRFSTMPETETHERETELFSPPSDVRGMTKLDRTAFKKTVNIPVLKVRKEIVSKLMRSLKRAALQRPGIRRVIEDPEDKESRLIMLDPYKIFTHDSFEKAELSVLEQLNVSPQISKYNLELTYEHFKSEEILRAVLPEGQDVTSGFSRIGHIAHLNLRDHQLSFKHLIGQVMIDKNPGITSAVNKINNIDNMYRNFQMEVLSGEQNMMTKVRENNYTYEFDFSKVYWNPRLSTEHSRITELLKPGDVLFDVFAGVGPFAIPVAKKNCTVFANDLNPESHKWLLYNCKLNKVDQKVKVFNLDGKDFLQGPVKEELMQLLGLSKERKPSVHVVMNLPAKAIEFLSAFKWLLDGQPCSSEFLPIVHCYSFSKDANPAEDVRQRAGAVLGISLEACSSVHLVRNVAPNKEMLCITFQIPASVLYKNQTRNPENHEDPPLKRQRTAEAFSDEKTQIVSNT

TRMT5

tRNA (guanine(37)-N1)-methyltransferase

509 amino acids

Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

58.106 kDa

MVLWILWRPFGFSRRLLKLERHSITESKSLIPLAWTSLTQTLSESPGIFLLGQRKRFSTMPEIETHEGDSELFSPPSDVRGMTKLDRTAFKKTVNIPVLKVRKEIVSRLMRSLRRAALQRPGIKRVIEDPEDKESRLILLDPYKIFTHDSFEKAGLSVLEQLNVSPQISKYNLELTYENFKSEEILRAVLPEGQDVTSGFSRVGHIAHLNLRDHQLPFKQLIGQVMIDKNPGITSAVNKINNIDNMYRNFHMEVLSGEQNMMTKVRENKYTYEFDFSKVYWNPRLSTEHSRITELLKAGDVLFDVFAGVGPFAIPVAKKNCTVFANDLNPESHKWLLHNCKLNKVDQKVKIFNLDGKDFLQGPVKEELIQLLSLSKERKPSVHIVMNLPAKAIEFLSAFKWLLDGQPCSNEFLPIVHCYSFSKDANPAKDVRQRAGAVLGISLEACSSVHLVRNVAPNKEMLCITFQIPAAVLYKNQTKNPENHEDPPLKRQRTAEAFSDEKTQIASNT

TRMT5

tRNA (guanine(37)-N1)-methyltransferase

509 amino acids

Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

58.277 kDa

MVLWILWRPFGFSRRLLKLERHSITESKSLIPLAWTSLTQTLSESPGIFLLGQRKRFSTMPEIETHERDSELFSPPSDVRGMTKLDRTAFKKTVNIPVLKVRKEIVSRLMRSLRRAALQRPGIKRVIEDPEDKESRLILLDPYKIFTHDSFEKAELSVLEQLNVSPQISKYNLELTYENFKSEEILRAVLPEGQDVTSGFSRVGHIAHLNLRDHQLPFKQLIGQVMIDKNPGITSAVNKINNIDNMYRNFHMEVLSGEQNMMTKVRENKYTYEFDFSKVYWNPRLSTEHSRITELLKAGDVLFDVFAGVGPFAIPVAKKNCTVFANDLNPESHKWLLHNCKLNKVDQKVKIFNLDGKDFLQGPVKEELIQLLSLSKERKPSVHIVMNLPAKAIEFLSAFKWLLDGQPCSNEFLPIVHCYSFSKDANPAKDVRQRAGAVLGISLEACSSVHLVRNVAPNKEMLCITFQIPAAVLYKNQTKNPENHEDPPLKRQRTAEAFSDEKTQIASNT

Trmt5

tRNA (guanine(37)-N1)-methyltransferase

501 amino acids

Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

56.794 kDa

MRIVWKLFGFSRRLLQVEWCHPSESILLFTLVPRLRKAPSVFLLGQRQGLSTMPEIEASVRDSELFSPPSDVRGMRELDRTAFKKTVSIPVLKARKEVVNRLMRALRRVALQRPGIKRVIEDPKDEDSRLIMLDPYRMLTADSFDKAELGVLKELDVSPQLSQYNLELTYENFKSEEILKAVLPEGQDVTSGFSRVGHIAHLNLRDHQLPFKHLIGQVMVDKNPGITSAVNKTSNIDNTYRNFQMEVLCGEENMLTKVRENNYTYEFDFSKVYWNPRLSTEHGRITELLNPGDVLFDVFAGVGPFAIPAARKNCTVFANDLNPESHKWLLHNCKLNKVDQKVKVFNMDGKDFIQGPVREELMLRLGLSAEAKPSVHIVMNLPAKAIEFLSVFRSLLDGQPCSTELLPTVHCYCFSKDSDPAKDVRQQAEAVLGVSLETSSSVHLVRNVAPNKEMLCITFQIPTATLYRNQSLSLQNDQEPPLKRQKTGDPFSGEPQIASDS

TRMT5

tRNA (guanine(37)-N1)-methyltransferase

497 amino acids

Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

56.954 kDa

MRSLLKQFAFSRRLLKVESCRITESASLILLPWASLIQKLNRVPVIFLLDQRKRFSTMPEIETNHRDSELFSPPSEVRGMTELDRTAFKKTVTIPVLKVRKEVVNKLMRSLKRAALQRPGIKRVIEDPEDGEGRLIMLDPYKMFTVDSFEKEELSILKQLNVNPQISKYNLDLTYENFKSEEILRAVLPEGQDVTSGFSRVGHIAHLNLRDHQLPYKHLIGQVMIDKNPGITSAVNKINNIDNTYRNFEMEVLSGEENMMTKVRENNYTYEFDFSKVYWNPRLSTEHSRITELLKPGDVLFDVFAGVGPFAIPAAKKKCTVFANDLNPESHKWLLHNCKLNKVDQKVKVFNLDGRDFLQGPVREELMQQLGPLSKERKHSVHIVMNLPAKAIEFLSAFKALLEGQPCGSELLPIVHCYSFSKDANPAKDVQQRAATVLGISLEAYSSVHLVRNVAPNKEMLCITFRIPAAILYKNQTVNRDNHEGPPLKRQRTDKDF

trmt5

tRNA (guanine(37)-N1)-methyltransferase

494 amino acids

Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

56.801 kDa

MRIRRILYFYGNLPNTYTANVLRRLAFSCWHTHQLPPTISATRSCFSAMAEMQDSHNEMELYSPNPEVRGMTCLNRDAFDKTIHVPVIKIKKEIINRLMKSLKHRLIQRPSLKRVIEDPKDDVNKLVLLDPYKVKSIDSFDESDHVLFKQFDVNPQVSQYELQLTYENFKCEEILRAVLPKGQDVTSGFSRVGHIAHMNLRDHQLPYKNVIGQVILDKNPGITSVVNKTNTIDSTYRNFQMEVLAGEENMITKVKENYVTYEFDFSKVYWNPRLGTEHNRIIGFLKARDVLFDVFAGVGPFAVPAAKKNCTVYANDLNPESYKWLLHNCKLNKVEKRVQAFNTDGRDFIKTTIKKELLKYADMPSAEEKPSLHIAMNLPALAVEFLDAFKNLLEEEPCNSFILPTIHCYSFSKDDDPLQDVKARAESFLGTTLEDCSMHLVRNVAPNKEMVCISFKLPSSVLFQRLSDTGEPESKRPRTAEAFPLPHVQQSRNS

trmt5

tRNA (guanine(37)-N1)-methyltransferase

480 amino acids

Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

54.047 kDa

MAAVWRRSARLFILLQRHHSCTFTSQNLNHFMRSQKVMTDQSQTDLGLFKPPSTVRGMTELDRSAFNQTVSVPAIRLPTNILNKAVKSLKKVALQRPGLKRVVEEHSEDGNADCGNIEHRLLLLDPNSITSSDSFGSDEAEALKAYSVPQEIQSYELKLTYENFKSEEILRAVLPEGQGVTSGFSRVGHIAHMNLREHQLPYRKLIGQVIIDKNPGITCVVNKTNTIDSTYRNFQMEVLAGESNMVAKVRENGVLYEFDFSRVYWNPRLSTEHERIVSLLHRGDTVVDVFAGVGPFAIPAARRGCAVLANDLNPESFRWLQHNAKLNKVDQKITTSNLDGRDFIRGPVRERLPALMKGSQKIHVVMNLPALALEFLDAFKGLLDPEPDQSLSNLPQVHCYGFSKENDPQRDVVERAEASLKTNLQGQCSVHLVRNVAPNKEMMCVSFTLPRGVLYKTHTQDRDTSEEPCPKKQKCEDSTN

trmt5

tRNA (guanine(37)-N1)-methyltransferase

460 amino acids

Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

52.313 kDa

MNVLNKEVFNQTKKVLGLIVSNKLVNGFSKQFKSYMFQSPKFKPIVSTDNDDKKMIYLCDTLKKETDIPDQLKTFIKENDIKVIEKDISLNYNNFSYEQVLKTLLPKDVGIPFSFERIGHIIHVNLKDEQLPFKYIIGQAILDKNIQVKTVLNKVGEIDTVFRTFKIEILAGEPDLVAEIKENECIFRFNFEEVYWNSRLQYEHMELVNTFKKEDIICDMFAGVGPFALPAAKIKKCKVYANDLNPSSVKYMKENAKTNRLESKVEISNLDARDFVKSLVEKSIPFTHVVMNLPSTSIEFLDVFRDIFLNSTIPPPIPPPIINCYTFTKLDESSDLIKDTIKNVENVIGAKVPSDYVCYEVRDVAPKKSMMRITFRMPTILPYVGSLTTASTTTTPTTSNTNTSTTTSTTSTSTTTTESTNTNNSANNVEDKNNKKRNSTEDSNETNETDSIDTNKKLKN

trmt5

tRNA (guanine(37)-N1)-methyltransferase

426 amino acids

Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

48.106 kDa

MSSLLLNKEIFSKSISIVGLKVNKTLLKTLAQEFKGYLLIRDRVKHIVDDSDSKDKKLVLLSESIENGNVGAYGVNKQLPDNLQSFLKTHSIEVVKHQVQLNYNNFSYEEVMKELIPTGLPIPHAFEKIGHIAHLNLKEELLPYKNMIGQVILDKKGPQIRTVLNKVGKIDTVFRTFNFELLAGDNDLLAQVVYWNSRLQFEHSNLIQTFKSHDIVVDMFAGVGPFAVPASKLVKCKVYANDLNPNSVKYMRENATRNKASTIEISNLDARDFVRELVSRDPPVAFTQAIMNLPSTSIEFLDVFREIFLNPEKAPPIPAPTIHCYTFTPVSETAGGDLKELTIKNVEAIIKHPLPADTTVYEVRDVSPNKRMMRISFKMPTLKKRKDTENNDDQENNNNSSNNNNNNKIDYNEAVSSGGEGKKIKH