Protein
tRNA (guanine(10)-N2)-dimethyltransferase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Function
Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity).
Similarity
Belongs to the methyltransferase superfamily. Trm-G10 family.
Sequence
MEMMVLLSQEHPELPSAELRSVLMSEGIDFSVIESGSGYEVIDAPRSTWKILKKRLAYAHEISEVIGYAAADDLDDAAEEIDWSKYVRESFAVRIRKLCGDVDSRTLERTIGAIIKEDTGLKVDLEKPWTLIRPVLINDRFILTRRLAVISKEHFNQARPHKRPFFYPGSMSPKLARCMVNLSGVKAGDRILDPFCGTGGILIEAGLMGVRVVGADIDWRMVEGTRENLQHYGITDFEVIRSDARDLRLDEKVDAIVTDPPYGISASTAGEKSEKLYREFLDSAHSNLAEGGMICMAAPHYLDLESLIDERFSIRERYSMRMHRSLTRVIRVIERV