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trmG10

Gene
trmG10
Protein
tRNA (guanine(10)-N2)-dimethyltransferase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
351 amino acids
Function
Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity).
Similarity
Belongs to the methyltransferase superfamily. Trm-G10 family.
Mass
40.483 kDa
Sequence
MIGYVLNGEHEEIPYGELMALLEIFNYNGSVERLKRYVITEDSPAKDIVKRSGYIDEGHRIIFRYNLEEKSVDLVDKIVNDFINSFKDFVANIDYPDIDESKSYAVRVLKLHKDEFTKSIDSLRIEKEIGGIIKLKTNAKVNLTKPDILVRVVILENTFFISNVLEMRDREYFQKNRPHLRKYFHPGCMLPKLARAMVNLARVKEGDIVLDPFCGTGGFLIEAGLIGAKLIGCDIDWRMASGTLINLEEYNLLDKVIKVKRLDAKYVKEFLNELNIEKVDAIVTDPPYGISTAKKGEIEKILETLPEVIKDNGYFVFAYPKKIELDMELEGLYKVYIHKGLIRHIHVYKKI

Gene
trmG10
Protein
tRNA (guanine(10)-N2)-dimethyltransferase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
336 amino acids
Function
Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity).
Similarity
Belongs to the methyltransferase superfamily. Trm-G10 family.
Mass
38.02 kDa
Sequence
MEMMVLLSQEHPELPSAELRSVLMSEGIDFSVIESGSGYEVIDAPRSTWKILKKRLAYAHEISEVIGYAAADDLDDAAEEIDWSKYVRESFAVRIRKLCGDVDSRTLERTIGAIIKEDTGLKVDLEKPWTLIRPVLINDRFILTRRLAVISKEHFNQARPHKRPFFYPGSMSPKLARCMVNLSGVKAGDRILDPFCGTGGILIEAGLMGVRVVGADIDWRMVEGTRENLQHYGITDFEVIRSDARDLRLDEKVDAIVTDPPYGISASTAGEKSEKLYREFLDSAHSNLAEGGMICMAAPHYLDLESLIDERFSIRERYSMRMHRSLTRVIRVIERV

Gene
trmG10
Protein
tRNA (guanine(10)-N2)-dimethyltransferase
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Length
329 amino acids
Function
Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G).
Similarity
Belongs to the methyltransferase superfamily. Trm-G10 family.
Mass
37.25 kDa
Sequence
MFYVEILGLLPEMAEAEVKALAELRNGTIKERDYLLVVGNVENVEIFERLGLAHEYGILLGSGDDVRDILDLVRGLEWKEIIKGTFAVRKEVMVNCAHEVKNLEKIIGGIIHSQGLRVNLSKPDTIIKVYCGRKLWIGIRIREFRGKEFDERKADRRPFSRPIALPPRIARAMVNLTRATREILDPFMGTGGMLIEAGLMGLKVYGIDIREDMVEGAKINLEYYGVKDYVVKVGDATKIKEAFPGKTFEAIATDPPYGTSTTLPMDRDELYKRALESMYSVLEGRLAIAFPSDFDALDVAETIGFKVIGRFYQRVHSSLSRYFYIMEAR

Gene
trmG10
Protein
tRNA (guanine(10)-N2)-dimethyltransferase
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
320 amino acids
Function
Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity).
Similarity
Belongs to the methyltransferase superfamily. Trm-G10 family.
Mass
36.673 kDa
Sequence
MKFLFYLSADNLEIARKEVLVLAERYGWVEDYQFEERLLLLDYAGEKFFERLAYTNEVTKIYDICSVSELEQVFSEIPVYDRLCCVRVKGGKGKTALERKLGALLWKRGAKVSVSNPEIVYKVYIQDDKCYVGLLEFERDTRQFFLRRPDRRPFLMPSAIKPKLARALVNLTGVLEGETLLDPMCGTGSFLIEAGLMGINPIGIDFIEKIVRGCRVNLEYYGIEGSVLLGDAKNLPLRDESVRGIATDYPYLRSTKAAGTLDELYSKTSEEFERVLKKGGRAAIVTNIDVESFFSNFEIEMKTEERVHGSLTRRIYLLRR

Gene
trmG10
Protein
Probable tRNA (guanine(10)-N2)-dimethyltransferase
Organism
Methanothermococcus thermolithotrophicus
Length
162 amino acids
Function
Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity).
Similarity
Belongs to the methyltransferase superfamily. Trm-G10 family.
Mass
18.186 kDa
Fragment
single
Sequence
KLAMCLVNLSRLKKGDVLLDPFCGTGGFLIEGGFMGLKLIGSDIDDDMVNGTLLNLKSYNLTEHIISIKKWNAGDIKSFLKQLNVKYVDGIVTDPPYGISTSAKGNIEEIFNNLGDVLKKDGYLVFASSRKINLDLELMEMYELYIHKSLTRYIHVYKKTDN