Protein
HTH-type transcriptional regulator TrmBL2
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Function
An abundant chromosomal protein that seems to be involved in both genome architecture and transcription repression. Incubation with DNA in vitro gives fibrous structures 14.2 +/- 2.1 nm in thickness (naked DNA is 1.83 +/- 0.37 nm); does not significantly compact DNA. Binds to both coding and non-coding regions; binding within gene promoters correlates with decreased transcript levels, while binding within coding regions does not.
Similarity
Belongs to the transcriptional regulator TrmB family.
Sequence
MVKDRMVELLQEHFELNLYEARAYVALVGFGVLTPAELASVSEVPAPRTYDVLRSLEKKGFAISQPGKVNKYRPVHPENILEKFIEEWQERVKEELEAKKKAKEELIELMKPLIETEIPKYGVERVWVVRGIRNATLKTKEMFEEVKEKILLADDGYIAINLENDLIKAIDNGAKAKIIVSKSLLKRLEGSKIMEYAKKGKLELRALDKFELPMLICDDEVFFALEDMAARYFNYETQVWIKDFRVRDLFEAKFNEYWEKAEKV