Protein
HTH-type sugar sensing transcriptional regulator TrmBL1
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function
Global transcriptional repressor of the maltodextrin transport gene cluster (mdxE operon) and most likely of all genes encoding glycolytic enzymes. Acts by binding to the conserved TGM (Thermococcales-Glycolytic-Motif) sequences in their promoter region. Can also interact with non-TGM sequences.
Similarity
Belongs to the transcriptional regulator TrmB family.
Sequence
MLEEEILQKLQKFGLTKYESLAYLTLLKLGPSKATDVTKESGIPHTRIYDVLSSLARKGFVDIVHGTPRLYAPVNPEIVLEKIREDLISDIERLKKAFQELYREVHGEELPEIWTVHGFENTIDRAQHIIRSAKHDILINTPYEFLEYLRGVLEKRNDVLIIVISNFSEIPLWLRNKNNVILARSGQAPWLLGTWVIGDINYALFFGTLPEDKGKERFYSFWVKSTRLIQNYVHWFYTMYFDNSEIVKPLNYERMEKPLTLSHIRTVITVLKQAGLPRNIEVIGRSLADKKQVTIKGKVIDYEYTPLTANITVKTDNKKIKVGGLGSYLEDIEGESFILLD