Protein
Transcription elongation factor spt4
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Sequence
MSENYVAPGQQRYLRACMVCSIVMTYARFRDEGCPNCEDFLHLQGSPDQIDSCTSQVFEGIITIANPQKSWVAKWQRLDGYVKGVYATKVSGQLPDDVRTTLEDDGIQYIPRDGSATEAD