TRAF3IP1

TRAF3-interacting protein 1

691 amino acids

Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity).

Belongs to the TRAF3IP1 family.

78.632 kDa

MNAAVVRRTQEALGKVIRRPPLTEKLLSKPPFRYLHDIITEVIRMTGFMKGLYTDAEMKSDNVKDKDAKISFLQKAIDVVVMVSGEPLLAKPARIVAGHEPERTNELLQIIGKCCLNKLSSDDAVRRVLAGEKGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERDRDSERKKETERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSVEGRKEDNISAKSLDSIVSGINNEPNQETTTSEIGTKEANINSTSISDDNSASLRCENIQPNPTEKQKGDSTSDAEGDAGPAGQDKSEVPETPEIPNELSSNIRRIPRPGSARPAPPRVKRQDSMEALQMDRSGSGKTVSNVITESHNSDNEEDDQFVVEAAPQLSEMSEIEMVTAVELEEEEKHGGLVKKILETKKDYEKLQQSPKPGEKERSLFESAWKKEKDIVSKEIEKLRTSIQTLCKSALPLGKIMDYIQEDVDAMQNELQMWHSENRQHAEALQQEQRITDCAVEPLKAELAELEQLIKDQQDKICAVKANILKNEEKIQKMVYSINLTSRR

Traf3ip1

TRAF3-interacting protein 1

653 amino acids

Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity).

Belongs to the TRAF3IP1 family.

74.114 kDa

MNAAVVRRTQEALGKVIRRPPLTEKLLNKPPFRYLHDIITEVIRITGFMKGLYTDAEMKSDNVKDKDAKISFLQKAIDVVMMVSGEPLAAKPARIVAGHEPERTNELLQLIGKCCLSKLSSDEAVKRVLAGEKGDSRGRVLRTSKAQEPDNKSVKEEESRTQKEEKRSSEVKERSSSAEHKQKEELKEDSKPREKERDKEKAKEADRDRHREPDRDRNRDGEREKARARAKQDRDRNNKDRDRETERDRDRDRRSDGGKEKERQKDRDRDKGKDRERRKSKNGEHTRDPDREKSRDADKSEKKADISVGASKSSTLKASKRRSKNSLEGRKEDNISAKILDSIVSGLNDEPDQETTAPEIDDNSASLWRENAEPEPAVKQKGDSPSDAEGEAVPTSQDKLEVTENAEVSNELPSSLRRIPRPGSARPAPPRVKRQESTETLAGDRSGSGKTVSTVIIDSQNSDNEDDEQFVVEAAPQLSEIAEIEMVPSGDLEDEEKHGGLVKKILETKKDYEKLQQSPKPGEKERSLIFESAWKKEKDIVSKEIEKLRVSIQTLCKSALPLGKIMDYIQEDVDAMQNELQLWHSENRQHAEALSKEQSITDSAVEPLKAELSELEQQIKDQQDKICAVKANILKNEEKIQKMVHSINLSSRR

traf3ip1

TRAF3-interacting protein 1

629 amino acids

Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity).

Belongs to the TRAF3IP1 family.

72.01 kDa

MNESVAKKTQETLGKVIKKPPLTEKLLSKPPFRYLHDIFSEVIRTTGFMKGLYVEAEMKSDNVKDKDSKIAFLQKAIDVVMLVSGEPLAAKPARIVAGHEPEKTNELLQVIAKCCLNKLSSDEAVKRVLAGDKLDQKGKPSTSRSQDKENREGREHHRDREERKGIKESSGSREQKDPDQPKDQESKRDDKDRRRDAERSDKGRERERTKDRDRDKDKSRDREKDKTREKEREREKDRNREKERERDKDRDKKKERESHKDRERDKDREREKRREKEKDKERPRETEEKLKDRGDRKIKAAEEISKSKPQPEVASRTHQAETEEAESPSRIPRPSSAKGQRRKPKTGGQGTEQDETESEGEAEGPSAEKPIPLENGDVTDPAALQTTHSRRLPRPSSARPAAPRVKRQESYTDATPAERLGSGKTPASVILDGKKLSEDEDDEDGQFVVEEAAPPPSDVPEVESNSLELQGDDKHGGLVKKILETKKDYESSPSSKSKEQDRSLVSEASRKKERELVAREIERLRSSIQTVCRSALPLGKIMDYIQEDMDSMQNELQSWRKENKENAQALLQEQRITDGVVEPLKVELAELEQLIKDQQDKICAVKSNILKNEEKIQKMVSSISFSSQT

Traf3ip1

TRAF3-interacting protein 1

625 amino acids

Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in epithelial morphogenesis and in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (PubMed:21945076).

Belongs to the TRAF3IP1 family.

71.037 kDa

MNAAVVRRTQEALGKVIRRPPLTEKLLNKPPFRYLHDIITEVIRITGFMKGLYTDAEMKSENVKDKDAKISFLQKAIDVVMMVSGEPLAAKPARIVAGHEPERTNELLQLIGKCCLSKLSSDEAVKRVLAGDKGDSRGRAQRTSKAQEPNNKSGKEEESRIHKEDKRSSEAKERSASAEHKQKEELKEDSKPREKERDKEKAKEADRDRHRDPDRDRNRDGEREKARARAKDRDRNNRDRDREAERDRERDRRSEGGKEKERVKDRDRDRDKGRDRERRKSKNGEHTRDPDREKSRDADKPEKKSSSSGEISRKLSDGSFKDVKAEMEADISVGASRSSTLKPSKRRSKHSLEGDSPSDAEVEAGPAGQDKPEVMENAEVPSELPSSLRRIPRPGSARPAPPRVKRQESTETLVVDRSGSGKTVSSVIIDSQNSDNEDDEQFVVEAAPQLSEIADIDMVPSGELEDEEKHGGLVKKILETKKDYEKLQQSLKPGEKERSLIFESAWKKEKDIVSKEIEKLRVSIQTLCKSALPLGKIMDYIQEDVDAMQNELQLWHSENRQHAEALSQEQSITDSAVEPLKAELSELEQQIRDQQDKICAVKANILKNEEKIQKMVHSINLSSRR