About Products Protein Database Contact

tra2

Gene
tra2
Protein
Transformer-2 protein homolog
Organism
Dictyostelium discoideum
Length
326 amino acids
Function
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
Similarity
Belongs to the splicing factor SR family.
Mass
36.586 kDa
Sequence
MEVADRMMSNGVDNDRRSSPSPHRGNGDMNNGNGNGNRDSRERSPPRGNSRERSPPRGGSPNRGGSPNRGGSPNRGGSPNRGGSPSRDDKRRYGNGGNGETRNRLANTASPSNVLGVFGLAPQTEERDLKDEFSRFGKIDHVDLIMDRKTGRSKCFGFVYFENKEDAVRAKEECQDLQLHGKSIRTDFSATKKPHEPTPGKYFGNPRYDSRRSPPRFSPYGGGDRYGRGDYGGRGGGGDRYGRDDRGGDRYGRDDRGGDRYGGRDDRGGDRYGGRDERGGDRGGDRYGRDDRDRHREDSRDRYNDRGGDRYNDRFRDERPRDSYRR

Gene
tra2
Protein
Transformer-2 sex-determining protein
Organism
Drosophila virilis
Length
272 amino acids
Function
Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female-specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to the dsxRE. Protein-RNA and protein-protein interactions are involved in tra-2 dependent activation and repression of alternative splicing (By similarity).
Similarity
Belongs to the splicing factor SR family.
Mass
31.841 kDa
Sequence
MSTGLVNAREKEYLHLHRIDKHKCSHSSATSSPSSAASSESSRTRQRRSDGEVYGSRHNNYKSSSQHRRRSRSGSDSPQVRHYSGRTSRDRQRMRQARDHPQASRCIGVFGLNTNTTQQKVRELFNKFGPIERIQMVIDAHTHRSRGFCFIYFENLGDARVAKDACTGMEVDGRRIRVDYSITQRAHTPTPGVYMGRPSRPLGRRSRERDYSTRDTSRSRRRHRDESSSVSPYDSNRRKYRSRHRYDRSRSRTRSYSRSRSPRKPVRVQSRY

Gene
tra2
Protein
Transformer-2 sex-determining protein
Organism
Drosophila melanogaster
Length
264 amino acids
Function
Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female-specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to the dsxRE. Protein-RNA and protein-protein interactions are involved in tra-2 dependent activation and repression of alternative splicing. Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site.
Similarity
Belongs to the splicing factor SR family.
Mass
31.031 kDa
Sequence
MDREPLSSGRLHCSARYKHKRSASSSSAGTTSSGHKDRRSDYDYCGSRRHQRSSSRRRSRSRSSSESPPPEPRHRSGRSSRDRERMHKSREHPQASRCIGVFGLNTNTSQHKVRELFNKYGPIERIQMVIDAQTQRSRGFCFIYFEKLSDARAAKDSCSGIEVDGRRIRVDFSITQRAHTPTPGVYLGRQPRGKAPRSFSPRRGRRVYHDRSASPYDNYRDRYDYRNDRYDRNLRRSPSRNRYTRNRSYSRSRSPQLRRTSSRY