tpp-2

Tripeptidyl-peptidase 2

1374 amino acids

Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Has a role in regulation of fat storage.

Belongs to the peptidase S8 family.

151.089 kDa

MIVIRNWQRISYLSFCRFSTRSLSIQQFQKTPLLLVVRQQGSARLKMTSSPPEIVPQQPLDALLLNKTDTEQEIFLTKYPNYDGRDILIAILDTGVDPSLPGMQVTTTGERKMFDVIDCSGAGDVDTSITRTVKDGVIEGISGRKLAIPEKWKCPTGQYHVGLKPIFELYTKGVKSRVISERKEDVVGPSHNIAASEALKQLTEHEKVVGGTSEKTSDKWAREDFACKVDFLKSMASVADVGPVADVVTWHDGEMWRVCIDTSFRGRLGLGNVLGTFRETGDYAYLTNKDSVVYTVRVSPDGNLTEIVVPSGAHGSHVAGIAAANYPDNPQKNGLAPGAKILSLNIGDHRLGAMETGQAMTRAFNMCAELNVDIINMSFGEGTHLPDVGRVIEEARRLINRRGVIYVCSAGNQGPALSTVGAPGGTTTGVIGIGAYLTSESADTLYGVYKPVESSIYPWSSRGPCQDGKLGVSLVAPAAAFAGVPQYCRQSMQMMNGTSMSSPNAAGNVACMLSGLKQNNLKWTPYTVRMALENTAYMLPHIESFSQGQGMIKIATAYEKLSEILVNKVFPPRLTHFEINVSNHCKKSKGVYVREPNWNGPQEFTIGVEPIFQNHLSDNNLPAISFEKQIILQSTAPWVSHPQTMFVVAQERTMVVTVDASKAPKGANYTEIVGIDTADPSLGPIFRIPVTVINPEKVAVDQYTSRLVGKSGVTERRFVEVPSWATSAKITLRSTNKDEMDRFTLHTVYIEDDKCSRNTETQKIQGPIGNEWSKSITVQGGKTLEACVVRAWSRGKNPVDVDMTIDFFGVKKPTSISLIHGATNTPIRFQAAPTKSIDVSPSISLKSLVVSLKPQSAKVEPLGPRDMFLTSGLQINRLLLTYQLKVQKPSEVQLQLAGLTPYLYESPVDCVLFQIFGANKSFVGASSSYPDRWTQKLEKGDYTIQAQIRYPDDQVLQGMKELPLLVHVKLGNKISVDLAASASDATLGKECKFAGKALLPNQEMTVYAMNIADDKLPKTIVPTSGSFLAGTFSALKDSDLSDVDKSEVIYFLSEYSTRPTKGLSMVTTKKDTNQNQEMTDAIRDLEVSWVQKLTDEKAAKEFFEACLQKYPDHLPLLQNRVKQLMQAKLVDQTPENVQKIIELCGQILQITKPNETLQFSSVKQEHDDDLLTVDKWLALTGGSEDQRKDVVKLISQFEERKKSIILALQALSSLEQDIEVRKSKFDVPASLRFGGITPLIFGGKQGEVINKKSEGYEALKSKSEQIDATVSEELKKLDSNWTGNQFYVKLLVWLSADDTKTALISAKHAAALGQFGRCAKLLNKAGDELKSSATDSQAVDTSLAEVCESLEWNHLATHFKNSALIKNRTSYRLF