Protein
Mitochondrial import receptor subunit tom22
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom20 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. Docks tom20 and tom70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating (By similarity).
Similarity
Belongs to the Tom22 family.
Sequence
MVQLTEVEDEHFQQPQVGPEEDDEDFTDTDSEISVDSDYESQETFTDRLYALRDMVSPTTRGWFYHKYSTTTNFVKSTLSFAGRAAWAVSVSGLLIGVPFAIAFAEDQNYAAMEQEARMRELGSDVLTAGGEGQAGTAEKTLAAIGGEGARPAL