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tom22

Gene
tom22
Protein
Mitochondrial import receptor subunit tom22
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
154 amino acids
Function
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom20 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. Docks tom20 and tom70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating (By similarity).
Similarity
Belongs to the Tom22 family.
Mass
16.816 kDa
Sequence
MVQLTEVEDEHFQQPQVGPEEDDEDFTDTDSEISVDSDYESQETFTDRLYALRDMVSPTTRGWFYHKYSTTTNFVKSTLSFAGRAAWAVSVSGLLIGVPFAIAFAEDQNYAAMEQEARMRELGSDVLTAGGEGQAGTAEKTLAAIGGEGARPAL

Gene
TOM22
Protein
Mitochondrial import receptor subunit TOM22
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
152 amino acids
Function
Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating.
Similarity
Belongs to the Tom22 family.
Mass
16.79 kDa
Sequence
MVELTEIKDDVVQLDEPQFSRNQAIVEEKASATNNDVVDDEDDSDSDFEDEFDENETLLDRIVALKDIVPPGKRQTISNFFGFTSSFVRNAFTKSGNLAWTLTTTALLLGVPLSLSILAEQQLIEMEKTFDLQSDANNILAQGEKDAAATAN

Gene
tom22
Protein
Mitochondrial import receptor subunit tom22
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
144 amino acids
Function
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom20 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. Docks tom20 and tom70 for interaction with the general tom40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating (By similarity).
Similarity
Belongs to the Tom22 family.
Mass
15.912 kDa
Sequence
MVKLEEVVDETEVQNEQQTVIEKDQYIYAQEDVEESDSDESDFEGLEEETIIDRIAALKEIVPVTWRVKIADGAKTATTGLSKLAQFGGKSMWVISTSALLLGVPFMMSLEEEAQLTEYEKQIKDQRGANEVIAPGATSGALPQ