Protein
Topoisomerase 1-associated factor 1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
Similarity
Belongs to the timeless family.
Sequence
MEAADINDDVVHPEVRAHITNLVSALGGYSADDDGSYKLGDEALDVLRDLKKWIRFYDEKTNRMDVARCLAEANLVGGDLLQILTLWPQSETDSKYKARIALACFEVMVPLTWPIEKERAEMTINHHRHMPVLQLAQLGYKRAIINFDAIPILNTAVRVALPSMAMPIGERTPRDQAIIKLILFFLRNVAMIAPPQGVKCEGDETQVSRSATIDAFSYQDIFLTLLTLASNMGEDFRTEDVVIMEIIFHLVKRVDPSSLFVSEKQLNKAKGQELASEMRKEAAMLKSYNKTTTTRHSRFGTMIWVKRADGKMVTVSGQEALLDAKTRERKMDNSKTFRPPRRARKPEMEPKDLGPPVTLDERARQQLRSFVQDFLDSGFNPLFLHVRQSIDREALHALNQHKSQFFYLVAWFLEAERMRRKAKRDESKSTSAAGEEVNSFNLVAAVLQQEMFASMNRALDRSYSDKDWQLLTSVMRCYTQIFLTVQEMSESPNEEDQEIAENTLSRLFYEETTHDLIANIARTYKDQGFEYLDAATELVHTFLRILEGYSKQNVDLQVRSRKRARRKKKAAKAAAAVAAARAAGEEAEDVGVPEDNDADDSGDDEQHAERVTQERKFEFGKFAIRFAPQGVVDTFVAFTKFYRDLNDAQLKRAHRYFYRVAFKLELSIMLFRLDIINLFYNMVQGPEPLDKSSPMFKEWEELSKQIIRKCVKKLQERPALFTELLFSKIGSTTHFLEHGYEKPVTTTTPRPGAELEFKRATERDEQIGIAVSVLIDKQQVEHLQWLKDQLTSAMSERQAWENVDKAMAATTEGAADGEAADERSNKSAPPHITIRPDTEARRTAMFKNPHLRLLMRLVGMERLTPTLDETPDSTWILPGSHTAEAIQDTIDLINKAEFSPPTFEDGGSAEDQLRRKSAAASRRTRAAYDDDEEEIRGFLGDDDDEDFLFAPGGPTARKPDARPQKKRQRKRRREAGSGDEEDEGVSDEVLAARAKKRREKELEKIRKIKSEMYVHASDDETDDERDREFFERERKRQETKDSKFDSMLGALGLSVLSQVNGGEKSAWEAVLDDEPESDESENEGRKNAKRRKKQVASGSEEEQEEEEEEEEEEDSDEELPTKQAKSKTSKRKAAVPSKRPARRPGTAKKRAVVELSDNDEDEDEEEDAMDVDSANERTTRNEAPLPSSPGEGLGRRIDKMAMDDGDEDEDDQPVVAARQRPKARGGFIIDSSDEE