Protein
Transmembrane protein 214-B
Function
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity).
Similarity
Belongs to the TMEM214 family.
Sequence
MASGAPDGKWKVVKKGKKSGERREGERKALTESNVTPGGTAPIKMANTVYEMGFDRIHKKQNKEQVPPNNMSSEQPQKQQQNPGKKKPQSGDSVCKQSKFHTLECALKALDVAELQRDLEKSQNMFPENPSIWVKDLAGYLNYKLQTVKNDVLIQQSHDYPYCLINKELKGIVRSLLAKAPHVLDVMVDHCIFSMLQELDKPTGESLHGYRICIQAVLLDKPKTVTSNLPKYLELLRSHLNRPMKCLTVMWAVGQAGFTDFTEGLKVWLGLMFPVLGVKNLTPYAILYLDRLLLAHSNLTKGFGMIGPKDFFPILDFAFMPNNSLTPSQQENLRNLYPKLKVLALGATPESTLHTYFPSFLSRATPSCPAEMRKELIHSLTDCLNKDSLSFSVWRQLYTKHLSQSSLLLQHLVETWDSNSRAMRKSVRETVHSFKVTNGEFSGKGSSSKDLEACDAACQALLHKMKSGGFPWWRLIVIAFVFLFGSVLYDVRTHNSFQESTSAQILQQSGLLSVSREAWNKVSNYSLQGQSWLERNVPQYYSQAVEVLGPVLEQVWAKTQEGGAYACEKGSVLLSYAKDNLPRLIEWLHSSIPDSVFQFIEYLRELLLHLHQTYLLPAVTYLEAAVQNSWQQYVKSCNGKVTWDCVRGQVGNISHSSWTYLQNTTMTFTNWALTIISRH