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tlk2

Gene
TLK2
Protein
Serine/threonine-protein kinase tousled-like 2
Organism
Homo sapiens
Length
772 amino acids
Function
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
87.661 kDa
Sequence
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN

Gene
Tlk2
Protein
Serine/threonine-protein kinase tousled-like 2
Organism
Mus musculus
Length
718 amino acids
Function
Testis-specific isoforms may play a role in spermatogenesis. Highly expressed in embryos throughout development.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
82.261 kDa
Sequence
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYDTSQGKGTPRGHKISDYFERRAEQPLYGLDGSAAKEASEEQSALPTLMSVMLAKPRLDTEQLAPRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN

Gene
tlk2
Protein
Serine/threonine-protein kinase tousled-like 2
Organism
Danio rerio
Length
697 amino acids
Function
Negative regulator of amino acid starvation-induced autophagy.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
79.305 kDa
Sequence
MMEELHSLDPRRQELLEARFTGVGVAKGSGHNESSNQSLCSVGSLSDKELETPEKKSNDQRTRKRKGDPFDSQGKGGGRGHKISDYFEFAGGSGTGTSPARGIPPVARSSPQHSLSNPPAAVQQGSPSSISSVNTDHSHTSTSHKPASIHTQHRASQSELTMEKLAALESSKSSDLEKKEGRIDDLLRVNCDLRRQIDEQQKMLEWCKERLNKCVTMSKKLLIEKSKQEKIACREKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLVKQQERVNGQREEIERQRKLLIKKKPPSASQTPPPNLEPNKRKSKSNGAENEMLSLAEYHEQEEIFKLRLGHLKKEEAEIQVELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQVVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDNYGVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATEVQFPPKPGVSPEAKAFIRRCLVYRKEDRIDVHQLASDPYLLPHIRKSVAATGNSSMAVASTSNSSNSSASN

Gene
tlk2
Protein
Serine/threonine-protein kinase tousled-like 2
Organism
Xenopus tropicalis
Length
697 amino acids
Function
Negative regulator of amino acid starvation-induced autophagy.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
80.071 kDa
Sequence
MMEELHSLDPRRQELLEARFTGVGVAKAPLNSESSNQSLCSLGSLSDKELEQTPEKKQNDQRNRKRKADPYETSQGKNTPRGHKISDYFEFACGSGPGTSPGRSVPPVARSSPQHSLSNPLPLPSQQCSPPSTAPVNPEHSCASFKHISVQHRCTQSDLTMDKISALENSKSSDLEKKEGRIDDLLRVNCDLRRQMDEQKKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINTQREEIERQRKMLAKRKPPAMGQTPPANNEQKQRKNKTNGAENEALTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMTEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSIPANAAVASTSGSSNNSLSN