TIM44

Mitochondrial import inner membrane translocase subunit TIM44

431 amino acids

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source.

Belongs to the Tim44 family.

48.854 kDa

MHRSTFIRTSGTSSRTLTARYRSQYTGLLVARVLFSTSTTRAQGGNPRSPLQIFRDTFKKEWEKSQELQENIKTLQDASGKLGESEAYKKAREAYLKAQRGSTIVGKTLKKTGETMEHIATKAWESELGKNTRKAAAATAKKLDESFEPVRQTKIYKEVSEVIDDGESSRYGGFITKEQRRLKRERDLASGKRHRAVKSNEDAGTAVVATNIESKESFGKKVEDFKEKTVVGRSIQSLKNKLWDESENPLIVVMRKITNKVGGFFAETESSRVYSQFKLMDPTFSNESFTRHLREYIVPEILEAYVKGDVKVLKKWFSEAPFNVYAAQQKIFKEQDVYADGRILDIRGVEIVSAKLLAPQDIPVLVVGCRAQEINLYRKKKTGEIAAGDEANILMSSYAMVFTRDPEQIDDDETEGWKILEFVRGGSRQFT

tim44

Mitochondrial import inner membrane translocase subunit tim44

427 amino acids

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (mge1) to drive protein translocation into the matrix using ATP as an energy source.

Belongs to the Tim44 family.

48.55 kDa

MFLSRKITKNARTIVQCQRFFQTSIFSQNAAPQSPIKVFMDTFRAELKKSQELQDSVKALQDSSGSLSESDTFKKARDAYEKARSGTTAASSFTGKTVGKAGAKIGSYAQKAWESAPVQLSKKVISSTANTVATGVDTATKPVRETAFYKTIKQTMSDGSTSSRYGFYADKEQRKKLREEFERRNRMFASSARIQPNEDVQSVVVHSNPSWKNKVEQIKNESRLVRKIQELKKSYQESEHPIVSSIRDMADSISGVWSRMFSETEASQVMRRFKEIDPSFNTEHFLQYLREYIVPEVTEAYVKGDKEVLKTWLSEAPFSVYETTTKEYAKHGVVSVGKILDIRGVDIMSQRLLQPNDIPVFIVTFRTQEVHMFKDASSGELVAGKDDRIQQCTYASVFTRVEDELDNPETRGWRIVDFARARAVDYF