Protein
Phosphomethylpyrimidine synthase 1
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Function
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Similarity
Belongs to the ThiC family.
Sequence
MTQMDEAKKGVITDEMKAVAEAENVTPEFVRRGVASGKIAIPSNLNREEVAAVGIGAGLRTKVNATIGTSTDIVDFDMEEEKARIAIENRADTLMELSVGGDLDEIRRRILDLSPIPVGSVPVYQAAIETIREKGASIYMDEDVMFRAIEKQAKDGIDFMAIHCSVNRETLRRLKRQGREGGLVSRGGAFVSAWMVENGLENPLYENFDYILEIAKEHDFVLSMANAMRAGAIADSTDRAQVQELIVLGELIDRAREAGVQTIVEGPGHIPLNEIKANVILQKKLCRGAPFYMLGPIVTDIGAGYDHIVSSIGAAASAAAGADFICYVTPAEHLALPYPDDVKEGVIATRIGAYVGDMVKGIHNGEKDLEMANARKKLNWEAQFDAAMCPAEARRIRDERPPEDPDTCTMCGEYCAVKIVNEWLDSADTRIFD