Protein
Tetracenomycin polyketide synthesis O-methyltransferase TcmP
Organism
Streptomyces glaucescens
Function
O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions: methylation of 8-O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 to 9-carboxymethyl-TCM B3.
Sequence
MGETIRLTGVHETLLATLQARALDNRQPRPVLGDATAEELLRRIDYDFSRIRTATKDMRIVTFRARKLDEWAGRFLAVHPDAVVLHLACGLDSRAFRMDVPDTVEWIDVDVPDVIELRSRLYPERDGYRMIGASVTTEDWLDTVPRNRPALVVAEGLTPYLREADGEEMLRRVIRHLPTGAVMFDAVLPWTLRFAKYSQLLRATGATFGWGIGNPRSLESRVPGLRFQEQWSMLDSPFLADARPVEKWVGAGMRSIPQLRFAHRLLRYTF