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tchp

Gene
tchp
Protein
Trichoplein keratin filament-binding protein
Organism
Danio rerio
Length
499 amino acids
Function
May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity).
Similarity
Belongs to the TCHP family.
Mass
62.351 kDa
Sequence
MALPTLSAHWPSRVRTLEQQLVRQREQEARLRRQWEQHSQYFREQDVRSSKQAQWSSRQSFHRSMSAFQRDRMREEKQRKLEERRERLRTMLQEERDQLEAELRNIHPDRDTLARQLVEKTDALRSAREERRKNLAQELLREHWKQNNSQLRKVESELHKDHIVSQWQVQQQEKKQADERTQEEKQRFENEYERTRQEALERMRKEEENRKWEEKKRAEELLKQMEELKLREQEAERLKQEQETLMSKRWELEKLEDERKMMEESRRKTEFGRFLTRQYRAQLKRRAQQVQEELEADRKILAALLEGELDEQRFHKARRERAVADAAWMKRVIEEQLQLEREREAEFDILYREEAQRVWEKREAEWEKERRARERLMREVLAGRQQQLQERMQENRLAREESLQRREELLQQLEQDRLTLRLEKEQQEGLRTARIQEIDNQVEQRRKEQWEQQQTLEQEEAQEREELRLQEEELRLETDRMIRQGFQERIHSRPRSAWT

Gene
tchp
Protein
Trichoplein keratin filament-binding protein
Organism
Xenopus laevis
Length
499 amino acids
Function
May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity).
Similarity
Belongs to the TCHP family.
Mass
61.197 kDa
Sequence
MALPTLPSNWHSRSRVLEQQIVRQREQEARLRHQWDQTNQYFKQSNVCSSKQAQWSSRQSYQKSMNAFHQEKQKEEKKKTLEYRREQLRKLLQEERDLLEEELKELRCNKEHNVSDMRQRTEELKSAREERQKQLAEELLYEQWKKNNVKLREVESSLFKKHVVDAWGEQITARNQEKEEEDMEKKRLENEYELARREAIERMKRDKEKRQQQEEELARVLKWQMEELKLKDLEAKKLKKEQEDLLRQQWEIEELEEERRKMEQCRKKTELSHFLSRQYNAQMKRRAQQVQEELEMDKKILSALISKEDEDQHLQSARREQAIADVAWMKHVIEEQLHLERQREAELDTLFREEAKQVWAKRETEWERERNARNRLMKEVLAGRQMQIQERIERNQLAQAESVMNRERLLRQLEEARQFTSREKKQEEEQKTARRTELEAQIAEQLLKGKEAIVQQEEEEKEFKLAEDLENDLLQQEAEIMTQRGYQKKTYSRPRTAWS

Gene
TCHP
Protein
Trichoplein keratin filament-binding protein
Organism
Homo sapiens
Length
498 amino acids
Function
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598).
Similarity
Belongs to the TCHP family.
Mass
61.072 kDa
Sequence
MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGHPKIAWN

Gene
TCHP
Protein
Trichoplein keratin filament-binding protein
Organism
Pongo abelii
Length
498 amino acids
Function
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity).
Similarity
Belongs to the TCHP family.
Mass
61.17 kDa
Sequence
MALPTLPFYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMREEQDLLARELEELRLSMNLQERRIREQHRKLKSAREEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVINSWETQKEEKKQQEATAEEENKRYENEYERAQREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLNRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVIADAAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEARESARREKEENEELKSARKQELEAQVAERQLQAWEADQQEKEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGHPKIAWN

Gene
Tchp
Protein
Trichoplein keratin filament-binding protein
Organism
Mus musculus
Length
497 amino acids
Function
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity).
Similarity
Belongs to the TCHP family.
Mass
60.642 kDa
Sequence
MALPTLPSYWSSRKHMDLRQRQHQQEDQFRQQWEQNSRYFRTWDIHNSKQIEWSSKISYQRSMHAYHCEKMKEEKRKILELRRERLRELLLEEQDLLAAELDELRLSMGLREQRLREQHQDLKSAREEQRKLIAERLLYEHWKKNNPKLRELELDLHKKHVINSWATQKEEKKQQEATEKQENKRLENQYAAARREAEARMRVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQLNRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAELQQLLREEAKEMWEKREAEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELEAQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPKLHGHLRIAWD