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tcf-29

Gene
tcf-29
Protein
General transcription and DNA repair factor IIH subunit tcf-29
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
663 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Similarity
Belongs to the TFB1 family.
Mass
73.03 kDa
Sequence
MAPIEIPRGQASYKKREGIITLTPDKTALIWSPLPGTGPPVISLSVSNITNLQQTPKTNPKVVLRVVEKPKAPGADPAAYPFQFTHATEARNEADAIKDLLSQIIAELRGDDPSLPKPAKSGPNGAGASAAMAMASAVNSKHLPFRWFEDDMLKADVELQQSLMKKDKALAHIYNDAKLSKPDSLSDASFNSQFWATRISLLRAYAIELNQKKGSYNVLSTIKPRTENGELKLNINHEQVQLIFQQHPLVKRIYNENVPKLTESEFWSRFFLSRLSKKLRGERITDNDNTDPLFDKYLEADNTMAVPAKITATSVPPIINIEGNEENQGGFRGGNLKDVEMRPRANIPIIKTLNSLSEKIMANVAPTDVDPSAASYSKDGIADALSKQLALQDLRGDAEAQLIRLSVKDTSTFFTGNQPSLTDQEAADARLYATQVPSDVLFEVQADMDTLDSDGRGGIDLHRSIGVDPDSDDEGNNSLDSKSGPKPQHVGSRAALRFAQNQILESMKSARSHLTTTTTHGGSHTTTTNASEERPMSLPTDIAHRATLTCATTAEFLKQFWTVFNNSSNSSPEKQQELAYLADSLVRSKQRIEALADEAEKRRQEIMEKRKREIREYYQKTGRKAKWVPVGGGRDAVWAAFEGVVGGLERAVAVWEMVKSGRI